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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-3-29
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pubmed:abstractText |
(a) We studied basal endothelial function in the insulin-resistant, obese Zucker rat, including the influence of superoxide anion on the regulation of contractile reactivity by nitric oxide (NO), following treatment in vivo with the antioxidant tiron or the pro-oxidant combination hydroquinone+buthionine sulfoximine. (b) The leftward shift in the contractile potency of phenylephrine due to NO synthase inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME) was greater in the isolated aorta of the obese Zucker rat relative to its insulin-sensitive littermate, the lean Zucker rat. (c) Pretreatment with tiron depressed vasoconstriction to phenylephrine and comparably enhanced the L-NAME-mediated leftward shift in contractile reactivity in the obese and lean Zucker rats in hydroquinone+buthionine sulfoximine-sensitive manner. (d) Our data therefore indicate superior endothelial function in the obese relative to the lean Zucker rat, reflected by a greater regulation of vasoconstrictor reactivity by basal NO, while the regulation of NO bioavailability by superoxide anion is similar.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Buthionine Sulfoximine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroquinones,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/hydroquinone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11922960-Animals,
pubmed-meshheading:11922960-Antimetabolites,
pubmed-meshheading:11922960-Antioxidants,
pubmed-meshheading:11922960-Body Weight,
pubmed-meshheading:11922960-Buthionine Sulfoximine,
pubmed-meshheading:11922960-Endothelium, Vascular,
pubmed-meshheading:11922960-Enzyme Inhibitors,
pubmed-meshheading:11922960-Hydroquinones,
pubmed-meshheading:11922960-Male,
pubmed-meshheading:11922960-Muscle, Smooth, Vascular,
pubmed-meshheading:11922960-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11922960-Nitric Oxide,
pubmed-meshheading:11922960-Nitric Oxide Synthase,
pubmed-meshheading:11922960-Obesity,
pubmed-meshheading:11922960-Oxidative Stress,
pubmed-meshheading:11922960-Phenylephrine,
pubmed-meshheading:11922960-Rats,
pubmed-meshheading:11922960-Rats, Zucker,
pubmed-meshheading:11922960-Superoxides,
pubmed-meshheading:11922960-Up-Regulation,
pubmed-meshheading:11922960-Vasoconstriction,
pubmed-meshheading:11922960-Vasoconstrictor Agents
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pubmed:year |
2000
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pubmed:articleTitle |
Investigation of basal endothelial function in the obese Zucker rat in vitro.
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pubmed:affiliation |
School of Pharmacy and Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK. david.laight@port.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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