Source:http://linkedlifedata.com/resource/pubmed/id/11920583
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-3-28
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| pubmed:abstractText |
The correlation between vascular endothelial growth factor (VEGF)-C gene expression and in vitro invasive activity and matrix metalloproteinase (MMP)-2 or 9 gene expression and proteolytic activity in 11 cervical carcinoma cell lines, was investigated. Immunohistochemical expression of VEGF-C in 52 cervical carcinoma tissues was also correlated with tumor aggressiveness with respect to clinicopathologic features, tumor vascularity, MMP-2 expression and patient outcome. Expression of VEGF-C mRNA differed remarkably among the cell lines and there was a statistical correlation between VEGF-C gene expression and the number of invaded tumor cells (p = 0.0009) and MMP-2 gene expression and activity (p < 0.05). Anti-VEGF-C antibody inhibited the invasive and proteolytic activity of tumor cells in a concentration-dependent manner. VEGF-C or MMP-2 expression in clinical tissue samples was well correlated with depth of myometrial invasion, endometrial invasion, pelvic lymphnode metastasis and tumor vascularity (p < 0.05) and there was a close relation between VEGF-C and MMP-2 expression (p < 0.0001) in cervical carcinomas. Overall survival rates for 14 patients with strong VEGF-C staining tumors were lower than those for 38 patients with weak VEGF-C staining tumors (p = 0.0132) and VEGF-C tissue status emerged as an independent prognostic parameter (p = 0.0232). These results suggest that VEGF-C expression is closely related to invasion phenotype and affects the patient's survival in cervical carcinomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor C
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0020-7136
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
20
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| pubmed:volume |
98
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
335-43
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:11920583-Adenocarcinoma,
pubmed-meshheading:11920583-Carcinoma, Squamous Cell,
pubmed-meshheading:11920583-DNA, Neoplasm,
pubmed-meshheading:11920583-DNA Primers,
pubmed-meshheading:11920583-Endothelial Growth Factors,
pubmed-meshheading:11920583-Female,
pubmed-meshheading:11920583-Gene Expression,
pubmed-meshheading:11920583-Humans,
pubmed-meshheading:11920583-Immunoenzyme Techniques,
pubmed-meshheading:11920583-Lymphatic Metastasis,
pubmed-meshheading:11920583-Matrix Metalloproteinase 2,
pubmed-meshheading:11920583-Matrix Metalloproteinase 9,
pubmed-meshheading:11920583-Middle Aged,
pubmed-meshheading:11920583-Phenotype,
pubmed-meshheading:11920583-RNA, Messenger,
pubmed-meshheading:11920583-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11920583-Survival Rate,
pubmed-meshheading:11920583-Tumor Cells, Cultured,
pubmed-meshheading:11920583-Uterine Cervical Neoplasms,
pubmed-meshheading:11920583-Vascular Endothelial Growth Factor C
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| pubmed:year |
2002
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| pubmed:articleTitle |
Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas.
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| pubmed:affiliation |
Department of Obstetrics and Gynecology, Osaka Medical College, Takasuki, Osaka, Japan. gyn017@poh.osaka-med.ac.jp
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| pubmed:publicationType |
Journal Article
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