Source:http://linkedlifedata.com/resource/pubmed/id/11920573
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2002-3-28
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| pubmed:abstractText |
TAPASIN, a V-C1 (variable-constant) immunoglobulin superfamily (IgSF) molecule that links MHC class I molecules to the transporter associated with antigen processing (TAP) in the endoplasmic reticulum (ER) is encoded by the TAPBP gene, located near to the MHC at 6p21.3. A related gene was identified at chromosome position 12p13.3 between the CD27 and VAMP1 genes near a group of MHC-paralogous loci. The gene, which we have called TAPBP-R (R for related), also encodes a member of the IgSF, TAPASIN-R. Its putative product contains similar structural motifs to TAPASIN, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. By using the mouse ortholog to screen tissue, we revealed that the TAPBP-R gene was broadly expressed. Sub-cellular localization showed that the bulk of TAPASIN-R is located within the ER but biotinylation experiments were consistent with some expression at thecell surface. TAPASIN-R lacks an obvious ER retention signal. The function of TAPASIN-R will be of interest in regards to the evolution of the immune system as well as antigen processing.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1059-68
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11920573-Amino Acid Motifs,
pubmed-meshheading:11920573-Amino Acid Sequence,
pubmed-meshheading:11920573-Animals,
pubmed-meshheading:11920573-Base Sequence,
pubmed-meshheading:11920573-Burkitt Lymphoma,
pubmed-meshheading:11920573-Chromosomes, Human, Pair 12,
pubmed-meshheading:11920573-DNA, Complementary,
pubmed-meshheading:11920573-Endoplasmic Reticulum,
pubmed-meshheading:11920573-Gene Expression,
pubmed-meshheading:11920573-Gene Library,
pubmed-meshheading:11920573-Genes,
pubmed-meshheading:11920573-HeLa Cells,
pubmed-meshheading:11920573-Humans,
pubmed-meshheading:11920573-Immunoglobulins,
pubmed-meshheading:11920573-Membrane Proteins,
pubmed-meshheading:11920573-Mice,
pubmed-meshheading:11920573-Molecular Sequence Data,
pubmed-meshheading:11920573-Multigene Family,
pubmed-meshheading:11920573-Protein Structure, Tertiary,
pubmed-meshheading:11920573-Recombinant Fusion Proteins,
pubmed-meshheading:11920573-Sequence Alignment,
pubmed-meshheading:11920573-Sequence Homology, Amino Acid,
pubmed-meshheading:11920573-Transfection,
pubmed-meshheading:11920573-Tumor Cells, Cultured
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
A human TAPBP (TAPASIN)-related gene, TAPBP-R.
|
| pubmed:affiliation |
Immunology Division, Department of Pathology, Cambridge, GB.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|