rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2002-3-28
|
pubmed:abstractText |
The factors that determine persistence or clearance of hepatitis C virus (HCV) infection are poorly understood. The CD4 T cell responses to the HCV core protein were examined in a cohort of women infected with a single genotype of HCV. CD4 T cells from HCV-infected patients secreted interferon (IFN)-gamma in response to peptides from 4 immunodominant regions of the core protein, and these responses were stronger in persistently infected women. Interleukin (IL)-10 was also produced by CD4 T cells from HCV-infected subjects in response to the same core peptides. Furthermore, HCV core-specific CD4 T cell clones secreted either IFN-gamma or IL-10 but not IL-4. These findings demonstrate that T helper type 1 and regulatory T cells are induced against the same epitopes on the core protein during HCV infection.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0022-1899
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
185
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
720-7
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:11920289-Adult,
pubmed-meshheading:11920289-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11920289-Epitopes, T-Lymphocyte,
pubmed-meshheading:11920289-Female,
pubmed-meshheading:11920289-HLA-DR Antigens,
pubmed-meshheading:11920289-HLA-DRB1 Chains,
pubmed-meshheading:11920289-Hepatitis C,
pubmed-meshheading:11920289-Humans,
pubmed-meshheading:11920289-Interferon-gamma,
pubmed-meshheading:11920289-Interleukin-10,
pubmed-meshheading:11920289-Interleukin-5,
pubmed-meshheading:11920289-Middle Aged,
pubmed-meshheading:11920289-Th1 Cells,
pubmed-meshheading:11920289-Viral Core Proteins
|
pubmed:year |
2002
|
pubmed:articleTitle |
CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons.
|
pubmed:affiliation |
Immune Regulation Research Group, Department of Biochemistry, Trinity College Dublin, Ireland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|