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| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C0021044 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C1521743 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C0181904 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C1704646 | lld:lifeskim |
| pubmed-article:11918659 | lifeskim:mentions | umls-concept:C0728873 | lld:lifeskim |
| pubmed-article:11918659 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11918659 | pubmed:dateCreated | 2002-3-28 | lld:pubmed |
| pubmed-article:11918659 | pubmed:abstractText | We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography (PET) imaging and postmortem analyses in a Parkinson's disease (PD) rat model induced by unilateral (right side) intrastriatal administration of 6-hydroxydopamine (6-OHDA). Degeneration of the dopamine system was monitored by PET imaging of presynaptic dopamine transporters using a specific ligand (11)C-CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane). Binding of (11)C-CFT was markedly reduced in the striatum indicating dopaminergic degeneration. Parallel PET studies of (11)C-PK11195 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3 isoquinoline carboxamide) (specific ligand for activated microglia) showed increased binding in the striatum and substantia nigra indicative of a microglial response. Postmortem immunohistochemical analyses were performed with antibodies against CR3 for microglia/macrophage activation. Using a qualitative postmortem index for microglial activation we found an initially focal, then widespread microglial response at striatal and nigral levels at 4 weeks postlesion. These data support the hypothesis that inflammation is a significant component of progressive dopaminergic degeneration that can be monitored by PET imaging. | lld:pubmed |
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| pubmed-article:11918659 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11918659 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11918659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11918659 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11918659 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:WilliamsKK | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:LivneAA | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:ChenY IYI | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:CicchettiFF | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:IsacsonOO | lld:pubmed |
| pubmed-article:11918659 | pubmed:author | pubmed-author:BrownellA LAL | lld:pubmed |
| pubmed-article:11918659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11918659 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:11918659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11918659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11918659 | pubmed:pagination | 991-8 | lld:pubmed |
| pubmed-article:11918659 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11918659 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11918659 | pubmed:articleTitle | Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. | lld:pubmed |
| pubmed-article:11918659 | pubmed:affiliation | Neuroregeneration Laboratory, MRC119, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. | lld:pubmed |
| pubmed-article:11918659 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11918659 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11918659 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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