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rdf:type |
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lifeskim:mentions |
umls-concept:C0011164,
umls-concept:C0013030,
umls-concept:C0021044,
umls-concept:C0032743,
umls-concept:C0034693,
umls-concept:C0085196,
umls-concept:C0181904,
umls-concept:C0205329,
umls-concept:C0596972,
umls-concept:C0728873,
umls-concept:C1521743,
umls-concept:C1704259,
umls-concept:C1704646,
umls-concept:C1705987
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pubmed:issue |
6
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pubmed:dateCreated |
2002-3-28
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pubmed:abstractText |
We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography (PET) imaging and postmortem analyses in a Parkinson's disease (PD) rat model induced by unilateral (right side) intrastriatal administration of 6-hydroxydopamine (6-OHDA). Degeneration of the dopamine system was monitored by PET imaging of presynaptic dopamine transporters using a specific ligand (11)C-CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane). Binding of (11)C-CFT was markedly reduced in the striatum indicating dopaminergic degeneration. Parallel PET studies of (11)C-PK11195 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3 isoquinoline carboxamide) (specific ligand for activated microglia) showed increased binding in the striatum and substantia nigra indicative of a microglial response. Postmortem immunohistochemical analyses were performed with antibodies against CR3 for microglia/macrophage activation. Using a qualitative postmortem index for microglial activation we found an initially focal, then widespread microglial response at striatal and nigral levels at 4 weeks postlesion. These data support the hypothesis that inflammation is a significant component of progressive dopaminergic degeneration that can be monitored by PET imaging.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD147,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bsg protein, Gallus gallus,
http://linkedlifedata.com/resource/pubmed/chemical/Bsg protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/PK 11195,
http://linkedlifedata.com/resource/pubmed/chemical/Sympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
991-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11918659-Animals,
pubmed-meshheading:11918659-Antigens, CD,
pubmed-meshheading:11918659-Antigens, CD147,
pubmed-meshheading:11918659-Antigens, Neoplasm,
pubmed-meshheading:11918659-Antigens, Surface,
pubmed-meshheading:11918659-Antineoplastic Agents,
pubmed-meshheading:11918659-Avian Proteins,
pubmed-meshheading:11918659-Blood Proteins,
pubmed-meshheading:11918659-Carbon Radioisotopes,
pubmed-meshheading:11918659-Dopamine,
pubmed-meshheading:11918659-Encephalitis,
pubmed-meshheading:11918659-Gliosis,
pubmed-meshheading:11918659-Isoquinolines,
pubmed-meshheading:11918659-Membrane Glycoproteins,
pubmed-meshheading:11918659-Microglia,
pubmed-meshheading:11918659-Neostriatum,
pubmed-meshheading:11918659-Neural Pathways,
pubmed-meshheading:11918659-Neurons,
pubmed-meshheading:11918659-Oxidopamine,
pubmed-meshheading:11918659-Parkinson Disease,
pubmed-meshheading:11918659-Rats,
pubmed-meshheading:11918659-Substantia Nigra,
pubmed-meshheading:11918659-Sympatholytics,
pubmed-meshheading:11918659-Tomography, Emission-Computed,
pubmed-meshheading:11918659-Tyrosine 3-Monooxygenase
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pubmed:year |
2002
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pubmed:articleTitle |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
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pubmed:affiliation |
Neuroregeneration Laboratory, MRC119, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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