Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-2
pubmed:databankReference
pubmed:abstractText
Approximately 10% of the photoreceptor outer segment (OS) is turned over each day, requiring large amounts of lipid and protein to be moved from the inner segment to the OS. Defects in intraphotoreceptor transport can lead to retinal degeneration and blindness. The transport mechanisms are unknown, but because the OS is a modified cilium, intraflagellar transport (IFT) is a candidate mechanism. IFT involves movement of large protein complexes along ciliary microtubules and is required for assembly and maintenance of cilia. We show that IFT particle proteins are localized to photoreceptor connecting cilia. We further find that mice with a mutation in the IFT particle protein gene, Tg737/IFT88, have abnormal OS development and retinal degeneration. Thus, IFT is important for assembly and maintenance of the vertebrate OS.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10069812, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10227290, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10399916, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10414956, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10545497, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10548469, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10549638, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10574761, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10722883, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10802659, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10804177, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-10943838, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-11062270, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-11251073, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-11290289, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-11301258, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-11676918, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-1623950, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-1656438, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-1706225, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-1977087, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-1986774, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-2826235, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-2939037, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-2948935, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-3172281, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-3249231, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-3693403, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-4747920, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-6033942, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-659071, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-7002220, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-7494458, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-7544404, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-8191288, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-8516294, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-8718680, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-8943080, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9114011, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9281580, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9475731, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9585416, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9585417, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9920666, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9950681, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9971734, http://linkedlifedata.com/resource/pubmed/commentcorrection/11916979-9971742
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-13
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