Source:http://linkedlifedata.com/resource/pubmed/id/11915020
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2002-3-26
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pubmed:abstractText |
Nonalcoholic fatty liver disease (NAFLD), a prevalent condition associated with obesity, has the potential of evolving into end-stage liver disease. The biochemical mechanisms that define the progression of NAFLD are not well known, but reactive oxygen species (ROS) have been implicated in this process. Uncoupling protein (UCP) 2 is a mitochondrial inner-membrane protein that mediates proton leak, uncouples adenosine triphosphate (ATP) synthesis, and negatively regulates ROS production. UCP2 expression is increased in various animal models of NAFLD. Up-regulation of UCP2 may compromise cellular ATP levels and worsen liver damage, or it may be protective by ROS reduction in NAFLD. This study aimed to obtain a definitive answer as to whether increased UCP2 expression contributes to NAFLD. UCP2-/- mice were exposed to obesity by crossbreeding with ob/ob mice and by long-term high-fat feeding to study the effect of UCP2 deficiency on the outcome of NAFLD. Steatohepatitis score of crossbred mice (ob/ob/ko) was similar to that of ob/ob mice at 25 weeks. No compensatory increase was observed in the expression of UCP5 in ob/ob/ko livers. To unmask the effects of absent leptin and its potential proinflammatory actions, steatosis was also induced in UCP2-/- mice by a high-fat diet continued for 6 months. Serum alanine aminotransferase (ALT) levels remained normal, and the steatohepatitis score in UCP2-/- mice was the same as in wild-type controls. We conclude that increased expression of UCP2 in the livers of mice with genetically or diet-induced obesity exerts neither protective nor deleterious effects on the severity of fatty liver disease.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Slc25a14 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 2
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
753-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11915020-Animals,
pubmed-meshheading:11915020-Carrier Proteins,
pubmed-meshheading:11915020-Dietary Fats,
pubmed-meshheading:11915020-Fatty Liver,
pubmed-meshheading:11915020-Ion Channels,
pubmed-meshheading:11915020-Liver,
pubmed-meshheading:11915020-Membrane Transport Proteins,
pubmed-meshheading:11915020-Mice,
pubmed-meshheading:11915020-Mice, Knockout,
pubmed-meshheading:11915020-Mitochondrial Proteins,
pubmed-meshheading:11915020-Nerve Tissue Proteins,
pubmed-meshheading:11915020-Obesity,
pubmed-meshheading:11915020-Phenotype,
pubmed-meshheading:11915020-Proteins,
pubmed-meshheading:11915020-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.
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pubmed:affiliation |
Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Gyorgy_Baffy@brown.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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