Linked Life Data

11913997

Source:http://linkedlifedata.com/resource/pubmed/id/11913997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-3-26
pubmed:abstractText
Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0268-960X
pubmed:author
pubmed:copyrightInfo
Copyright 2002, Elsevier Science Ltd. All rights reserved.
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The potential role of thrombopoietin in idiopathic thrombocytopenic purpura.
pubmed:affiliation
Department of Medicine, Clinical Hematology, University of Amsterdam, Amsterdam, The Netherlands. a.vondemborne@amc.uva.nl
pubmed:publicationType
Journal Article, Review