Linked Life Data

11912138

Source:http://linkedlifedata.com/resource/pubmed/id/11912138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-3-25
pubmed:abstractText
The angiogenic factor vascular endothelial growth factor-D (VEGF-D) isa ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and receptor-2 (VEGFR-2/KDR)and is implicated in the development of lymphatic vessels and promotion of lymphatic metastases. We assessed the expression of VEGF-D and VEGFR-3 in relation to microvessel density (MVD) in colorectal carcinomas (CRC), adenomas, and adjacent normal tissue by immunohistochemistry on consecutive archival sections. VEGF-D was detected in malignant and benign epithelium and in some smooth muscle of the colorectum. High-grade VEGF-D expression was observed frequently (74%) in CRC compared with adenomas (0%) and adjacent normal mucosa (22%). High-grade VEGF-D expression was not correlated with MVD, Dukes' stage (A to C), or tumor differentiation, but was associated with lymphatic involvement and patient survival. By multivariate analysis, VEGF-D expression was found to be an independent prognostic factor for both disease-free and overall survival. VEGFR-3 expression was detected in a subset of vessels, typically thin-walled and devoid of RBCs, in 89% of CRC cases examined. VEGFR-3-positive vessel densities increased progressively from normal mucosa to adenomas and carcinomas and were correlated with MVD, but not with Dukes' stage (A to C), tumor differentiation, or VEGF-D expression. VEGFR-3 expression was spatially associated with macrophage-rich inflammatory infiltrates, which were significantly more frequent among VEGFR-3-positive cases. We conclude that VEGF-D expression, but not that of its receptor VEGFR-3, is an independent prognostic indicator in CRC. VEGF-D expression may be associated with disease outcome through the promotion of lymphatic involvement/metastases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1669-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11912138-Adenoma, pubmed-meshheading:11912138-Aged, pubmed-meshheading:11912138-Colorectal Neoplasms, pubmed-meshheading:11912138-Endothelial Growth Factors, pubmed-meshheading:11912138-Female, pubmed-meshheading:11912138-Humans, pubmed-meshheading:11912138-Immunohistochemistry, pubmed-meshheading:11912138-Intestinal Mucosa, pubmed-meshheading:11912138-Male, pubmed-meshheading:11912138-Neovascularization, Pathologic, pubmed-meshheading:11912138-Precancerous Conditions, pubmed-meshheading:11912138-Prognosis, pubmed-meshheading:11912138-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:11912138-Receptors, Growth Factor, pubmed-meshheading:11912138-Tumor Markers, Biological, pubmed-meshheading:11912138-Vascular Endothelial Growth Factor D, pubmed-meshheading:11912138-Vascular Endothelial Growth Factor Receptor-3
pubmed:year
2002
pubmed:articleTitle
Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma.
pubmed:affiliation
University of Nottingham Laboratory of Molecular Oncology, Cancer Research Campaign Department of Clinical Oncology, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't