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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1976-1-26
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pubmed:abstractText |
Neutral and alkaline sucrose gradient sedimentation analysis was used to measure double- and single-strand breaks in the DNA of Chinese hamster ovary (CHO) cells exposed to either gamma- or alpha-radiation. After irradiation, cells were incubated for 15-180 min to test the ability of the cell to rejoin the DNA breaks. Essentially complete rejoining was observed for single-strand breaks induced by gamma- or alpha-doses below 20 krad and for double-strand breaks induced by gamma doses below 60 krad. Approximately 80% rejoining was observed for double-strand breaks induced by alpha doses below 40 krad. At higher doses, the repair system appeared to saturate in such a way that essentially no additional breaks were rejoined.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0090-5542
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
665-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1191188-Alpha Particles,
pubmed-meshheading:1191188-Cell Line,
pubmed-meshheading:1191188-Centrifugation, Density Gradient,
pubmed-meshheading:1191188-DNA,
pubmed-meshheading:1191188-DNA, Single-Stranded,
pubmed-meshheading:1191188-DNA Repair,
pubmed-meshheading:1191188-Dose-Response Relationship, Radiation,
pubmed-meshheading:1191188-Gamma Rays,
pubmed-meshheading:1191188-Molecular Weight,
pubmed-meshheading:1191188-Radiation Effects
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pubmed:year |
1975
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pubmed:articleTitle |
CHO cell repair of single-strand and double-strand DNA breaks induced by gamma- and alpha-radiations.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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