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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-3-22
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pubmed:abstractText |
A series of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre-contracted with carbachol. Several 1,3-diaryl 1,2,4-(4H)-triazol-5-one derivatives were found to be potent smooth muscle relaxants but this activity did not completely correlate with maxi-K channel opening.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1117-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11909730-Animals,
pubmed-meshheading:11909730-Azo Compounds,
pubmed-meshheading:11909730-Calcium,
pubmed-meshheading:11909730-Carbachol,
pubmed-meshheading:11909730-Cells, Cultured,
pubmed-meshheading:11909730-Electrophysiology,
pubmed-meshheading:11909730-Humans,
pubmed-meshheading:11909730-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:11909730-Male,
pubmed-meshheading:11909730-Mice,
pubmed-meshheading:11909730-Microinjections,
pubmed-meshheading:11909730-Models, Molecular,
pubmed-meshheading:11909730-Muscle, Smooth,
pubmed-meshheading:11909730-Muscle Relaxation,
pubmed-meshheading:11909730-Oocytes,
pubmed-meshheading:11909730-Potassium Channels, Calcium-Activated,
pubmed-meshheading:11909730-RNA, Messenger,
pubmed-meshheading:11909730-Rats,
pubmed-meshheading:11909730-Structure-Activity Relationship,
pubmed-meshheading:11909730-Urinary Bladder,
pubmed-meshheading:11909730-Urinary Incontinence,
pubmed-meshheading:11909730-Xenopus laevis
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pubmed:year |
2002
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pubmed:articleTitle |
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.
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pubmed:affiliation |
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. hewawasp@bms.com
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pubmed:publicationType |
Journal Article
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