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rdf:type |
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lifeskim:mentions |
umls-concept:C0032824,
umls-concept:C0220781,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0916884,
umls-concept:C0965615,
umls-concept:C1531444,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1880022,
umls-concept:C1883254
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pubmed:issue |
7
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pubmed:dateCreated |
2002-3-22
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pubmed:abstractText |
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral resolution. Cloned maxi-K channels are opened by 1, which demonstrates a brain/plasma ratio >9 in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BoissardChristopher GCG,
pubmed-author:DworetzkySteven ISI,
pubmed-author:GribkoffValentin KVK,
pubmed-author:HewawasamPiyasenaP,
pubmed-author:HugWW,
pubmed-author:KnipeJayJ,
pubmed-author:MartinezEduardoE,
pubmed-author:MeanwellNicholas ANA,
pubmed-author:PajorLorraine MLM,
pubmed-author:PendriYadagiriY,
pubmed-author:PerroneRobertR,
pubmed-author:Post-MunsonDebra JDJ,
pubmed-author:StarrettJohn EJEJr,
pubmed-author:TrojnackiJoanne TJT,
pubmed-author:YeleswaramKrishnaswamyK
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1023-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11909708-Animals,
pubmed-meshheading:11909708-Brain,
pubmed-meshheading:11909708-Calcium,
pubmed-meshheading:11909708-Cells, Cultured,
pubmed-meshheading:11909708-Diazonium Compounds,
pubmed-meshheading:11909708-Humans,
pubmed-meshheading:11909708-Indoles,
pubmed-meshheading:11909708-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:11909708-Male,
pubmed-meshheading:11909708-Microinjections,
pubmed-meshheading:11909708-Oocytes,
pubmed-meshheading:11909708-Patch-Clamp Techniques,
pubmed-meshheading:11909708-Potassium Channels, Calcium-Activated,
pubmed-meshheading:11909708-RNA, Messenger,
pubmed-meshheading:11909708-Rats,
pubmed-meshheading:11909708-Rats, Sprague-Dawley,
pubmed-meshheading:11909708-Xenopus
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pubmed:year |
2002
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pubmed:articleTitle |
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
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pubmed:affiliation |
Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
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pubmed:publicationType |
Journal Article
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