rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2002-3-22
|
pubmed:abstractText |
A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI(50)=0.205 microM) and HT-29 colon cancer (GI(50)=0.554 microM), respectively.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1013-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11909706-Antineoplastic Agents,
pubmed-meshheading:11909706-Benzene,
pubmed-meshheading:11909706-Cell Division,
pubmed-meshheading:11909706-Drug Screening Assays, Antitumor,
pubmed-meshheading:11909706-Humans,
pubmed-meshheading:11909706-Models, Molecular,
pubmed-meshheading:11909706-Molecular Conformation,
pubmed-meshheading:11909706-Molecular Structure,
pubmed-meshheading:11909706-Neoplasms,
pubmed-meshheading:11909706-Stilbenes,
pubmed-meshheading:11909706-Structure-Activity Relationship,
pubmed-meshheading:11909706-Sulfonamides,
pubmed-meshheading:11909706-Tumor Cells, Cultured
|
pubmed:year |
2002
|
pubmed:articleTitle |
Antitumor agents. Part 3: synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives.
|
pubmed:affiliation |
Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan. lmyang@cma23.nricm.edu.tw
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|