|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2002-3-21
|
|
pubmed:abstractText |
Mutations in the Caenorhabditis elegans unc-84 gene cause defects in nuclear migration and anchoring. We show that endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear envelope and that the envelope localization of UNC-84 requires Ce-lamin. We also show that during mitosis, UNC-84 remains at the nuclear periphery until late anaphase, similar to known inner nuclear membrane proteins. UNC-84 protein is first detected at the 26-cell stage and thereafter is present in most cells during development and in adults. UNC-84 is properly expressed in unc-83 and anc-1 lines, which have phenotypes similar to unc-84, suggesting that neither the expression nor nuclear envelope localization of UNC-84 depends on UNC-83 or ANC-1 proteins. The envelope localization of Ce-lamin, Ce-emerin, Ce-MAN1, and nucleoporins are unaffected by the loss of UNC-84. UNC-84 is not required for centrosome attachment to the nucleus because centrosomes are localized normally in unc-84 hyp7 cells despite a nuclear migration defect. Models for UNC-84 localization are discussed.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10375507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10444068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10504295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10508607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10508861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10579712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10588867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10725321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10806082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10806083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-10982402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-11071918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-11165516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-11593002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-11748140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-4277710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-7262539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-7744953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11907270-7790369
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ce-MAN1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lamins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Pore Complex Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thymopoietins,
http://linkedlifedata.com/resource/pubmed/chemical/Unc-84 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/emerin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1059-1524
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
892-901
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11907270-Animals,
pubmed-meshheading:11907270-Caenorhabditis elegans,
pubmed-meshheading:11907270-Caenorhabditis elegans Proteins,
pubmed-meshheading:11907270-Centrosome,
pubmed-meshheading:11907270-Gene Expression Regulation, Developmental,
pubmed-meshheading:11907270-Helminth Proteins,
pubmed-meshheading:11907270-Lamins,
pubmed-meshheading:11907270-Membrane Glycoproteins,
pubmed-meshheading:11907270-Membrane Proteins,
pubmed-meshheading:11907270-Mitosis,
pubmed-meshheading:11907270-Models, Biological,
pubmed-meshheading:11907270-Nuclear Envelope,
pubmed-meshheading:11907270-Nuclear Pore Complex Proteins,
pubmed-meshheading:11907270-Nuclear Proteins,
pubmed-meshheading:11907270-Recombinant Fusion Proteins,
pubmed-meshheading:11907270-Thymopoietins
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.
|
|
pubmed:affiliation |
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
