Source:http://linkedlifedata.com/resource/pubmed/id/11907126
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2002-3-21
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| pubmed:abstractText |
The pathogenesis of Crohn's disease (CD) remains under intense investigation. Increasing evidence suggests a role for mature IL-18 in the induction of proinflammatory cytokines and Th1 polarization in CD lesions. The aim of this study was to investigate the contribution of the IL-18-neutralizing (a and c) and non-neutralizing (b and d) isoforms of IL-18-binding protein (IL-18BP) during active CD. Intestinal endothelial cells and macrophages were the major source of IL-18BP within the submucosa, and this IL-18BP production was also found to be relevant to other types of endothelial cells (HUVEC) and macrophages (peripheral monocytes). IL-18BP messenger transcript and protein were significantly increased in surgically resected specimens from active CD compared with control patients, correlating with an up-regulation of IL-18. Analysis of the expression of the four IL-18BP isoforms as well as being free or bound to IL-18 was reported and revealed that unbound IL-18BP isoforms a and c and inactive isoform d were present in specimens from active CD and control patients while isoform b was not detected. IL-18/IL-18BP complex was also detected. Interestingly, although most was complexed, free mature IL-18 could still be detected in active CD specimens even in the presence of the IL-18BP isoform a/c. These results demonstrate that the appropriate neutralizing isoforms are present in the intestinal tissue of patients with active CD and highlights the complexity of IL-18/IL-18BP biology.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-18 binding protein
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1767
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| pubmed:author |
pubmed-author:BelzerIlanaI,
pubmed-author:ChvatchkoYolandeY,
pubmed-author:CorbazAnneA,
pubmed-author:DinarelloCharles ACA,
pubmed-author:GraberPierreP,
pubmed-author:HarrisonJillianJ,
pubmed-author:HerrenSuzanneS,
pubmed-author:KimSoo-HyunSH,
pubmed-author:Kosco-VilboisMarie HMH,
pubmed-author:NovickDanielaD,
pubmed-author:PlitzThomasT,
pubmed-author:SchwartsburdBorisB,
pubmed-author:ten HoveTessaT,
pubmed-author:van DeventerSanderS
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
168
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3608-16
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11907126-Adult,
pubmed-meshheading:11907126-Aged,
pubmed-meshheading:11907126-Aged, 80 and over,
pubmed-meshheading:11907126-Cells, Cultured,
pubmed-meshheading:11907126-Colon,
pubmed-meshheading:11907126-Crohn Disease,
pubmed-meshheading:11907126-Endothelium, Vascular,
pubmed-meshheading:11907126-Female,
pubmed-meshheading:11907126-Glycoproteins,
pubmed-meshheading:11907126-Humans,
pubmed-meshheading:11907126-Ileum,
pubmed-meshheading:11907126-Immunohistochemistry,
pubmed-meshheading:11907126-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11907126-Interleukin-18,
pubmed-meshheading:11907126-Intestinal Mucosa,
pubmed-meshheading:11907126-Macrophages,
pubmed-meshheading:11907126-Male,
pubmed-meshheading:11907126-Middle Aged,
pubmed-meshheading:11907126-Umbilical Veins,
pubmed-meshheading:11907126-Up-Regulation
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| pubmed:year |
2002
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| pubmed:articleTitle |
IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.
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| pubmed:affiliation |
Department of Experimental Biology and Pharmacology, Serono Pharmaceutical Research Institute, Geneva, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|