Source:http://linkedlifedata.com/resource/pubmed/id/11907107
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2002-3-21
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| pubmed:abstractText |
Until now it was thought that the retrovirus mouse mammary tumor virus preferentially infects B cells, which thereafter proliferate and differentiate due to superantigen-mediated T cell help. We describe in this study that dendritic cells are infectable at levels comparable to B cells in the first days after virus injection. Moreover, IgM knockout mice have chronically deleted superantigen-reactive T cells after MMTV injection, indicating that superantigen presentation by dendritic cells is sufficient for T cell deletion. In both subsets initially only few cells were infected, but there was an exponential increase in numbers of infected B cells due to superantigen-mediated T cell help, explaining that at the peak of the response infection is almost exclusively found in B cells. The level of infection in vivo was below 1 in 1000 dendritic cells or B cells. Infection levels in freshly isolated dendritic cells from spleen, Langerhans cells from skin, or bone marrow-derived dendritic cells were compared in an in vitro infection assay. Immature dendritic cells such as Langerhans cells or bone marrow-derived dendritic cells were infected 10- to 30-fold more efficiently than mature splenic dendritic cells. Bone marrow-derived dendritic cells carrying an endogenous mouse mammary tumor virus superantigen were highly efficient at inducing a superantigen response in vivo. These results highlight the importance of professional APC and efficient T cell priming for the establishment of a persistent infection by mouse mammary tumor virus.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
168
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3470-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11907107-Adoptive Transfer,
pubmed-meshheading:11907107-Animals,
pubmed-meshheading:11907107-Antigen Presentation,
pubmed-meshheading:11907107-B-Lymphocyte Subsets,
pubmed-meshheading:11907107-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11907107-Cell Differentiation,
pubmed-meshheading:11907107-Cells, Cultured,
pubmed-meshheading:11907107-Clonal Deletion,
pubmed-meshheading:11907107-Dendritic Cells,
pubmed-meshheading:11907107-Interphase,
pubmed-meshheading:11907107-Lymph Nodes,
pubmed-meshheading:11907107-Lymphopenia,
pubmed-meshheading:11907107-Mammary Tumor Virus, Mouse,
pubmed-meshheading:11907107-Mice,
pubmed-meshheading:11907107-Mice, Inbred BALB C,
pubmed-meshheading:11907107-Mice, Inbred DBA,
pubmed-meshheading:11907107-Mice, Knockout,
pubmed-meshheading:11907107-Retroviridae Infections,
pubmed-meshheading:11907107-Superantigens,
pubmed-meshheading:11907107-Tumor Virus Infections
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus.
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| pubmed:affiliation |
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|