Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-3-21
pubmed:abstractText
Minor histocompatibility Ags elicit cell-mediated immune responses and graft rejection in individuals receiving MHC-matched tissues. H60 represents a dominant Ag that elicits a strong CTL response in C57BL/6 mice immunized against BALB.B. An 8-aa peptide in the H60 protein is presented by H-2K(b) and this is recognized by the TCR as an alloantigen. The intact H60 glycoprotein is a ligand for the costimulatory NKG2D receptor that is expressed by activated CD8(+) T cells. Thus, H60 may provide both an allogeneic peptide and its own costimulation. We show that mutation of an H-2K(b)-binding anchor residue in the H60 peptide completely abrogates binding of H60 glycoprotein to NKG2D and a synthetic H60 peptide partially blocks the binding of NKG2D to its ligand. Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens, http://linkedlifedata.com/resource/pubmed/chemical/H-2Kb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes, http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Minor Histocompatibility Antigens, http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell, http://linkedlifedata.com/resource/pubmed/chemical/minor H antigen H60
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3131-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11907062-Animals, pubmed-meshheading:11907062-Antigen Presentation, pubmed-meshheading:11907062-Binding, Competitive, pubmed-meshheading:11907062-Cell Line, pubmed-meshheading:11907062-Cytotoxicity, Immunologic, pubmed-meshheading:11907062-Cytotoxicity Tests, Immunologic, pubmed-meshheading:11907062-H-2 Antigens, pubmed-meshheading:11907062-Immunodominant Epitopes, pubmed-meshheading:11907062-Killer Cells, Natural, pubmed-meshheading:11907062-Mice, pubmed-meshheading:11907062-Mice, Inbred BALB C, pubmed-meshheading:11907062-Mice, Inbred C57BL, pubmed-meshheading:11907062-Minor Histocompatibility Antigens, pubmed-meshheading:11907062-Mutagenesis, Site-Directed, pubmed-meshheading:11907062-NK Cell Lectin-Like Receptor Subfamily K, pubmed-meshheading:11907062-Oligopeptides, pubmed-meshheading:11907062-Protein Binding, pubmed-meshheading:11907062-Receptors, Antigen, T-Cell, pubmed-meshheading:11907062-Receptors, Immunologic, pubmed-meshheading:11907062-Receptors, Natural Killer Cell, pubmed-meshheading:11907062-Solubility
pubmed:year
2002
pubmed:articleTitle
Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D.
pubmed:affiliation
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.