Source:http://linkedlifedata.com/resource/pubmed/id/11905810
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-3-21
|
| pubmed:abstractText |
In the past decade, advances in genetic engineering and mouse knockout technology have transformed our understanding of the immune system. In particular, new perspectives on T-cell development, co-stimulation and activation have emerged from the study of single and multiple gene-knockout animals, as well as from conditional knockout and 'knock-in' mutants. Analysis of these animals has clarified important intracellular signalling pathways and has shed light on the regulatory mechanisms that govern normal immune responses and autoimmunity.
|
| pubmed:language |
eng
|
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:author | |
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11905810-Animals,
pubmed-meshheading:11905810-Gene Targeting,
pubmed-meshheading:11905810-Genetic Engineering,
pubmed-meshheading:11905810-Lymphocyte Activation,
pubmed-meshheading:11905810-Mice,
pubmed-meshheading:11905810-Mice, Knockout,
pubmed-meshheading:11905810-Models, Immunological,
pubmed-meshheading:11905810-Signal Transduction,
pubmed-meshheading:11905810-T-Lymphocytes
|
| pubmed:articleTitle |
Knockout mice: a paradigm shift in modern immunology.
|
| pubmed:affiliation |
Amgen Research Institute, Toronto, Ontario, Canada. tmak@oci.utoronto.ca
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|