| pubmed-article:11904421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11904421 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:11904421 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:11904421 | lifeskim:mentions | umls-concept:C2936267 | lld:lifeskim |
| pubmed-article:11904421 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:11904421 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11904421 | pubmed:dateCreated | 2002-3-20 | lld:pubmed |
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| pubmed-article:11904421 | pubmed:abstractText | Telomeres are usually maintained about an equilibrium length, and the set point for this equilibrium differs between species and between strains of a given species. To examine the requirement for telomerase in mediating establishment of a new telomere length equilibrium, we generated interspecies crosses with telomerase mTR knockout mice. In crosses between C57BL/6J (B6) and either of two unrelated mouse species, CAST/Ei and SPRET/Ei, telomerase mediated establishment of a new telomere length equilibrium in wild-type mTR(+/+) mice. This new equilibrium was characterized by elongation of the short telomeres of CAST/Ei or SPRET/Ei origin. In contrast, mTR(-/-) offspring of interspecies crosses failed to elongate telomeres. Unexpectedly, haploinsufficiency was observed in mTR(+/-) heterozygous interspecies mice, which had an impaired ability to elongate short SPRET/Ei or CAST/Ei telomeres to the new equilibrium set point that was achieved in wild-type mTR(+/+) mice. These results demonstrate that elongation of telomeres to a new telomere set point requires telomerase and indicate that telomerase RNA may be limiting in vivo. | lld:pubmed |
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| pubmed-article:11904421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11904421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11904421 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11904421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11904421 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11904421 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:OppermanKay... | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:GreiderCarol... | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:HodesRichard... | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:HathcockKaren... | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:HemannMichael... | lld:pubmed |
| pubmed-article:11904421 | pubmed:author | pubmed-author:StrongMargare... | lld:pubmed |
| pubmed-article:11904421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11904421 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11904421 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:11904421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11904421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11904421 | pubmed:pagination | 3591-6 | lld:pubmed |
| pubmed-article:11904421 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11904421 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11904421 | pubmed:articleTitle | Haploinsufficiency of mTR results in defects in telomere elongation. | lld:pubmed |
| pubmed-article:11904421 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:11904421 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11904421 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11904421 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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