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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-3-20
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pubmed:databankReference |
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pubmed:abstractText |
Telomeres are usually maintained about an equilibrium length, and the set point for this equilibrium differs between species and between strains of a given species. To examine the requirement for telomerase in mediating establishment of a new telomere length equilibrium, we generated interspecies crosses with telomerase mTR knockout mice. In crosses between C57BL/6J (B6) and either of two unrelated mouse species, CAST/Ei and SPRET/Ei, telomerase mediated establishment of a new telomere length equilibrium in wild-type mTR(+/+) mice. This new equilibrium was characterized by elongation of the short telomeres of CAST/Ei or SPRET/Ei origin. In contrast, mTR(-/-) offspring of interspecies crosses failed to elongate telomeres. Unexpectedly, haploinsufficiency was observed in mTR(+/-) heterozygous interspecies mice, which had an impaired ability to elongate short SPRET/Ei or CAST/Ei telomeres to the new equilibrium set point that was achieved in wild-type mTR(+/+) mice. These results demonstrate that elongation of telomeres to a new telomere set point requires telomerase and indicate that telomerase RNA may be limiting in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-10328870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-10454554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-10721988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11071935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11092831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11102810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11452000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11574891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-11904422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-1356536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-2170845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-2175882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-2342578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-2463488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-2982162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-7605428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-8733138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-8811183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-8848051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-9034193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-9335332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-9560153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-9637478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11904421-9671732
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3591-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11904421-Animals,
pubmed-meshheading:11904421-Crosses, Genetic,
pubmed-meshheading:11904421-Female,
pubmed-meshheading:11904421-Gene Deletion,
pubmed-meshheading:11904421-Genotype,
pubmed-meshheading:11904421-Male,
pubmed-meshheading:11904421-Mice,
pubmed-meshheading:11904421-Mice, Inbred C57BL,
pubmed-meshheading:11904421-Mice, Inbred Strains,
pubmed-meshheading:11904421-Mice, Knockout,
pubmed-meshheading:11904421-Molecular Sequence Data,
pubmed-meshheading:11904421-Phenotype,
pubmed-meshheading:11904421-RNA,
pubmed-meshheading:11904421-Species Specificity,
pubmed-meshheading:11904421-Telomerase,
pubmed-meshheading:11904421-Telomere
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pubmed:year |
2002
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pubmed:articleTitle |
Haploinsufficiency of mTR results in defects in telomere elongation.
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pubmed:affiliation |
Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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