| pubmed-article:11901201 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1414264 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C0083956 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11901201 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11901201 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11901201 | pubmed:dateCreated | 2002-3-19 | lld:pubmed |
| pubmed-article:11901201 | pubmed:abstractText | The rae28 gene (rae28), also designated as mph1, is a mammalian ortholog of the Drosophila polyhomeotic gene, a member of Polycomb group genes (PcG). rae28 constitutes PcG complex 1 for maintaining transcriptional states which have been once initiated, presumably through modulation of the chromatin structure. Hematopoietic activity was impaired in the fetal liver of rae28-deficient animals (rae28-/-), as demonstrated by progressive reduction of hematopoietic progenitors of multilineages and poor expansion of colony forming units in spleen (CFU-S(12)) during embryonic development. An in vitro long-term culture-initiating cell assay suggested a reduction in hematopoietic stem cells (HSCs), which was confirmed in vivo by reconstitution experiments in lethally irradiated congenic recipient mice. The competitive repopulating units (CRUs) reflect HSCs supporting multilineage blood-cell production. CRUs were generated, whereas the number of CRUs was reduced by a factor of 20 in the rae28-/- fetal liver. We also performed serial transplantation experiments to semiquantitatively measure self-renewal activity of CRUs in vivo. Self-renewal activity of CRUs was 15-fold decreased in rae28-/-. Thus the compromised HSCs were presumed to reduce hematopoietic activity in the rae28-/- fetal liver. This is the first report to suggest that rae28 has a crucial role in sustaining the activity of HSCs to maintain hematopoiesis. | lld:pubmed |
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| pubmed-article:11901201 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11901201 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11901201 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11901201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11901201 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11901201 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11901201 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:HumphriesR... | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:AkihisaSawada... | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:TokimasaSadao... | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:OhtaHideakiH | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:KimJi YooJY | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:HaraJunichiJ | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:NishiguchiSei... | lld:pubmed |
| pubmed-article:11901201 | pubmed:author | pubmed-author:TakiharaYoshi... | lld:pubmed |
| pubmed-article:11901201 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11901201 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:11901201 | pubmed:volume | 195 | lld:pubmed |
| pubmed-article:11901201 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11901201 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11901201 | pubmed:pagination | 759-70 | lld:pubmed |
| pubmed-article:11901201 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:meshHeading | pubmed-meshheading:11901201... | lld:pubmed |
| pubmed-article:11901201 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11901201 | pubmed:articleTitle | Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. | lld:pubmed |
| pubmed-article:11901201 | pubmed:affiliation | Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3 Nakamichi-1, Higashinari, Osaka 537-8511, Japan. | lld:pubmed |
| pubmed-article:11901201 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11901201 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:13619 | entrezgene:pubmed | pubmed-article:11901201 | lld:entrezgene |
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