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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0015295,
umls-concept:C0017337,
umls-concept:C0205147,
umls-concept:C0237401,
umls-concept:C0332285,
umls-concept:C0525410,
umls-concept:C0598089,
umls-concept:C0752046,
umls-concept:C1412077,
umls-concept:C1441547,
umls-concept:C1556094,
umls-concept:C1882417
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pubmed:issue |
4
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pubmed:dateCreated |
2002-3-19
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pubmed:abstractText |
We found nucleotide variability in the 5'-upstream region and exonic sequences of a gene-encoding canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2 (cMOAT/MRP2) by polymerase chain reaction-based sequencing using genomic DNA from 72 established cell lines derived from 72 Japanese individuals. Four single nucleotide polymorphisms (SNPs) were found in the 5'-untranslational region and 21 in the exonic regions. Of them, 14 were nonsynonymous SNPs. One deletion of seven consecutive adenines resulting in a frameshift variant was also found. Four SNPs, c-24t, g1249a (V417I), c2366t (S789F), and c3972t (I1324I), were the same as those recently reported. A strong association was found between c-24t (5'-untranslated region) and c3972t (exon 28), with the promoter activity of the former worth being compared.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0090-9556
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pubmed:author |
pubmed-author:IshidaSeiichiS,
pubmed-author:ItodaMasayaM,
pubmed-author:MurayamaNorieN,
pubmed-author:NaganoMichiyoM,
pubmed-author:OzawaShogoS,
pubmed-author:SaekiMayumiM,
pubmed-author:SaiKimieK,
pubmed-author:SaitoYoshiroY,
pubmed-author:Sawada JiJun-ichiJ,
pubmed-author:SoyamaAkikoA,
pubmed-author:SugiyamaYuichiY,
pubmed-author:SuzukiHiroshiH
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11901087-5' Untranslated Regions,
pubmed-meshheading:11901087-Amino Acid Substitution,
pubmed-meshheading:11901087-Asian Continental Ancestry Group,
pubmed-meshheading:11901087-Cell Line,
pubmed-meshheading:11901087-Exons,
pubmed-meshheading:11901087-Genomic Library,
pubmed-meshheading:11901087-Humans,
pubmed-meshheading:11901087-Japan,
pubmed-meshheading:11901087-Membrane Transport Proteins,
pubmed-meshheading:11901087-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:11901087-Polymerase Chain Reaction,
pubmed-meshheading:11901087-Polymorphism, Single Nucleotide,
pubmed-meshheading:11901087-Sequence Analysis, DNA
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pubmed:year |
2002
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pubmed:articleTitle |
Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.
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pubmed:affiliation |
Project Team for Pharmacogenetics, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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