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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-3-19
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pubmed:abstractText |
The cytotoxic T lymphocyte-associated antigen 4 gene (CTLA-4) encode the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. The receptor protein is a specific T lymphocyte surface antigen that is detected on cells only after antigen presentation. Thus, CTLA-4 is directly involved in both immune and autoimmune responses and may be involved in the pathogenesis of multiple T cell-mediated autoimmune disorders. There is polymorphism at position 49 in exon 1 of the CTLA-4 gene, providing an A-G exchange. Moreover, we assessed the CTLA-4 49 (Thr/Ala) polymorphism in diabetic patients and first-degree relatives as compared to control subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ alpha-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQA1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:issn |
1560-4284
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11900275-Alleles,
pubmed-meshheading:11900275-Antigens, CD,
pubmed-meshheading:11900275-Antigens, Differentiation,
pubmed-meshheading:11900275-Base Sequence,
pubmed-meshheading:11900275-Biological Markers,
pubmed-meshheading:11900275-CTLA-4 Antigen,
pubmed-meshheading:11900275-DNA Primers,
pubmed-meshheading:11900275-Diabetes Mellitus, Type 1,
pubmed-meshheading:11900275-Family,
pubmed-meshheading:11900275-Female,
pubmed-meshheading:11900275-France,
pubmed-meshheading:11900275-Gene Frequency,
pubmed-meshheading:11900275-Genotype,
pubmed-meshheading:11900275-HLA-DQ Antigens,
pubmed-meshheading:11900275-HLA-DQ alpha-Chains,
pubmed-meshheading:11900275-HLA-DQ beta-Chains,
pubmed-meshheading:11900275-Humans,
pubmed-meshheading:11900275-Immunoconjugates,
pubmed-meshheading:11900275-Male,
pubmed-meshheading:11900275-Polymerase Chain Reaction,
pubmed-meshheading:11900275-Polymorphism, Genetic,
pubmed-meshheading:11900275-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:11900275-Reference Values,
pubmed-meshheading:11900275-Risk Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes.
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pubmed:affiliation |
Centre Européen d'Etude du Diabète-H?pitaux Universitaires de Strasbourg. jean-claude.ongagna@wanadoo.fr
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pubmed:publicationType |
Journal Article,
Comparative Study
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