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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 3
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pubmed:dateCreated |
2002-3-18
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pubmed:abstractText |
We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-10331577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-10639398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-10673553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-11110810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-11127836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-11134516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-11134520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-11135257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-112679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-1709528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-2573073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-7637804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-7724066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-7909839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-8113445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-8557842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-8613722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-8978474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-9295391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-9356427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-9453665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11897842-9877021
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
539
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
707-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11897842-Animals,
pubmed-meshheading:11897842-Dopamine,
pubmed-meshheading:11897842-Electric Stimulation,
pubmed-meshheading:11897842-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11897842-Macaca fascicularis,
pubmed-meshheading:11897842-Male,
pubmed-meshheading:11897842-Patch-Clamp Techniques,
pubmed-meshheading:11897842-Prefrontal Cortex,
pubmed-meshheading:11897842-Pyramidal Cells,
pubmed-meshheading:11897842-Receptors, Dopamine D1,
pubmed-meshheading:11897842-Receptors, Dopamine D2,
pubmed-meshheading:11897842-Synaptic Transmission
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pubmed:year |
2002
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pubmed:articleTitle |
Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex.
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pubmed:affiliation |
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. urban@mpimf-heidelberg.mpg.de
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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