| pubmed-article:11897497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:11897497 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:11897497 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11897497 | pubmed:dateCreated | 2002-3-18 | lld:pubmed |
| pubmed-article:11897497 | pubmed:abstractText | We have compared early signaling events at various stages of B cell differentiation using established mouse cell lines. Clustering of pre-B cell antigen receptor (BCR) or BCR induced the tyrosine phosphorylation of various proteins in all cells, although the phosphorylation pattern differed. In spite of the pre-BCR-induced tyrosine phosphorylation, we could not detect an intracellular Ca(2+) signal in pre-B cells. However, co-clustering of the pre-BCR with CD19 did induce Ca(2+) mobilization. In contrast to the immature and mature B cells, where the B cell linker protein (BLNK) went through inducible tyrosine phosphorylation upon BCR clustering, we observed a constitutive tyrosine phosphorylation of BLNK in pre-B cell lines. Both BLNK and phospholipase C (PLC)gamma were raft associated in unstimulated pre-B cells, and this could not be enhanced by pre-BCR engagement, suggesting a ligand-independent PLC gamma-mediated signaling. Further results indicate that the cell lines representing the immature stage are more sensitive to BCR-, CD19- and type II receptors binding the Fc part of IgG (Fc gamma RIIb)-mediated signals than mature B cells. | lld:pubmed |
| pubmed-article:11897497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11897497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11897497 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11897497 | pubmed:issn | 0898-6568 | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:KurosakiTomoh... | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:HaimovichJose... | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:IshiaiMasamic... | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:KövesdiDorott... | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:KonczGáborG | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:Iványi-NagyRo... | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:CaspiYaelY | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:GergelyJánosJ | lld:pubmed |
| pubmed-article:11897497 | pubmed:author | pubmed-author:SármayGabriel... | lld:pubmed |
| pubmed-article:11897497 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11897497 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:11897497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11897497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11897497 | pubmed:pagination | 563-72 | lld:pubmed |
| pubmed-article:11897497 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11897497 | pubmed:meshHeading | pubmed-meshheading:11897497... | lld:pubmed |
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| pubmed-article:11897497 | pubmed:meshHeading | pubmed-meshheading:11897497... | lld:pubmed |
| pubmed-article:11897497 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11897497 | pubmed:articleTitle | Developmental differences in B cell receptor-induced signal transduction. | lld:pubmed |
| pubmed-article:11897497 | pubmed:affiliation | Department of Immunology, Loránd Eötvös University, H-1117 Pázmány Péter sétány 1/C, Budapest, Hungary. | lld:pubmed |
| pubmed-article:11897497 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11897497 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11897497 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11897497 | lld:pubmed |
