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rdf:type |
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lifeskim:mentions |
umls-concept:C0009014,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0037925,
umls-concept:C0205527,
umls-concept:C0243192,
umls-concept:C0443254,
umls-concept:C0531859,
umls-concept:C1152725,
umls-concept:C1521797,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-18
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pubmed:abstractText |
We examined the role of the spinal muscarinic receptor subtype in the anti-nociceptive effect of intrathecal (i.t.) alpha2 adrenoceptor agonist clonidine in mice. I.t. injection of the muscarinic receptor antagonist atropine completely inhibited i.t. clonidine-induced increase in the mechanical threshold, but did not affect the increase in tail-flick latency induced by i.t. clonidine. The clonidine-induced increase in mechanical threshold was inhibited by i.t. injection of the M1 receptor antagonist pirenzepine in a dose-dependent manner, and by the M3 receptor antagonist 4-DAMP, but not by the M2 receptor antagonist methoctramine. The potency of pirenzepine was greater than that of 4-DAMP. These results suggest that the clonidine-induced increase in mechanical threshold is mediated via the activation of M1 receptors in the spinal cord.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
322
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11897163-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:11897163-Adrenergic alpha-Agonists,
pubmed-meshheading:11897163-Adrenergic alpha-Antagonists,
pubmed-meshheading:11897163-Analgesics,
pubmed-meshheading:11897163-Animals,
pubmed-meshheading:11897163-Clonidine,
pubmed-meshheading:11897163-Hot Temperature,
pubmed-meshheading:11897163-Injections, Spinal,
pubmed-meshheading:11897163-Male,
pubmed-meshheading:11897163-Mechanoreceptors,
pubmed-meshheading:11897163-Mice,
pubmed-meshheading:11897163-Muscarinic Antagonists,
pubmed-meshheading:11897163-Pain Measurement,
pubmed-meshheading:11897163-Pain Threshold,
pubmed-meshheading:11897163-Physical Stimulation,
pubmed-meshheading:11897163-Reaction Time,
pubmed-meshheading:11897163-Receptor, Muscarinic M1,
pubmed-meshheading:11897163-Receptors, Muscarinic,
pubmed-meshheading:11897163-Spinal Cord,
pubmed-meshheading:11897163-Synaptic Transmission,
pubmed-meshheading:11897163-Yohimbine
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pubmed:year |
2002
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pubmed:articleTitle |
Intrathecal alpha2 adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M1 receptors.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814-0180, Japan. khonda@fukuoka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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