Linked Life Data

11896720

Source:http://linkedlifedata.com/resource/pubmed/id/11896720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-3-18
pubmed:abstractText
The copper(II) complex of lincomycin in water solution at pH = 7.15 was characterized by (1)H and (13)C NMR and UV-vis spectroscopy. A 1:1 complex is formed in these conditions. The temperature dependence of spin-lattice relaxation rates was measured, showing that all protons behave in a similar fashion and slow exchange conditions prevail. The spin-lattice relaxation rate enhancements were interpreted by the Solomon-Bloembergen-Morgan theory. Reorientational dynamics of the complex was approximated by evaluating the motional correlation time of free lincomycin in water solution. The observed proton and carbon relaxation rate enhancements allowed us to calculate copper-proton and copper-carbon distances that were used for building a molecular model of the complex. The obtained data provide an interpretation of the relatively high stability constant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0020-1669
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1518-22
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Structure and dynamics of the lincomycin-copper(II) complex in water solution by (1)H and (13)C NMR studies.
pubmed:affiliation
Department of Chemistry, University of Siena, Via Aldo Moro, 53100 Siena, Italy.
pubmed:publicationType
Journal Article