Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-3-15
pubmed:abstractText
A 40 year old man with hereditary multiple exostoses (HME), affecting predominantly his left proximal tibia, distal femur, and proximal femur, underwent resection of an osteochondroma near the trochanter major of his left proximal femur because of malignant transformation of the cartilaginous cap towards secondary peripheral chondrosarcoma. The patient had a history of a papillary thyroid carcinoma four years previously. At examination of the resected specimen, a third malignant tumour, an intermediate grade osteosarcoma (grade II/IV), was found in the osseous stalk of the osteochondroma. Although no mutations were found in the EXT1 and EXT2 genes, the genes involved in HME, or in exons 5-8 of the p53 gene, the development of three malignancies before the age of 40 suggests that this patient is genetically prone to malignant transformation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-10441575, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-10458834, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-10502322, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-10547601, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-10629543, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-11073818, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-11140704, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-2575586, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-3344216, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-3409256, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-7550340, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-8081357, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-8782816, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-8894688, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-9620772, http://linkedlifedata.com/resource/pubmed/commentcorrection/11896078-9665133
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9746
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma. A case report of a patient with hereditary multiple exostoses.
pubmed:affiliation
Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, 2300 RC Leiden, The Netherlands.
pubmed:publicationType
Journal Article, Case Reports