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rdf:type |
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lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0023452,
umls-concept:C0043335,
umls-concept:C0087111,
umls-concept:C0679058,
umls-concept:C0871261,
umls-concept:C1258083,
umls-concept:C1337112,
umls-concept:C1547699,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2700640,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-15
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|
pubmed:abstractText |
The most common childhood malignancy, acute lymphoblastic leukemia (ALL), remains the leading cause of cancer-related death in children because of resistant cases in which underlying predisposing factors are poorly understood. The interindividual variation in the activity of xenobiotic metabolizing enzymes that modify individual somatic mutation burden in the context of environmental exposure was shown to modify susceptibility to childhood ALL. Variable DNA repair capacity may further modulate induced DNA lesions. Similarly, differential capacity of ALL patients to process carcinogens and chemotherapeutic drugs could both modify an individual's risk of recurrent malignancy and response to therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
802-10
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11895912-Acetyltransferases,
pubmed-meshheading:11895912-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11895912-Child,
pubmed-meshheading:11895912-Child, Preschool,
pubmed-meshheading:11895912-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11895912-DNA Repair,
pubmed-meshheading:11895912-Disease Susceptibility,
pubmed-meshheading:11895912-Genotype,
pubmed-meshheading:11895912-Glutathione Transferase,
pubmed-meshheading:11895912-Humans,
pubmed-meshheading:11895912-Infant,
pubmed-meshheading:11895912-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:11895912-Polymorphism, Genetic,
pubmed-meshheading:11895912-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:11895912-Prognosis,
pubmed-meshheading:11895912-Survival Rate,
pubmed-meshheading:11895912-Treatment Outcome,
pubmed-meshheading:11895912-Xenobiotics
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pubmed:year |
2002
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pubmed:articleTitle |
Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia.
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pubmed:affiliation |
Service d'Hématologie-Oncologie, Centre de Recherche, Hôpital Sainte-Justine, Montréal, Quebec, H3T 1C5 Canada. maja.krajinovic@umontreal.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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