Source:http://linkedlifedata.com/resource/pubmed/id/11895764
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2002-3-15
|
| pubmed:abstractText |
Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin 6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with Kaposi sarcoma-associated herpesvirus, also called human herpesvirus type 8 (KSHV/HHV8). Within a prospective cohort study on 60 HIV-infected patients with MCD, and a median follow-up period of 20 months, 14 patients developed KSHV/HHV8-associated non-Hodgkin lymphoma (NHL): 3 "classic" KSHV/HHV8(+) Epstein-Barr virus-positive (EBV(+)) primary effusion lymphoma (PEL), 5 KSHV/HHV8(+) EBV(-) visceral large cell NHL with a PEL-like phenotype, and 6 plasmablastic lymphoma/leukemia (3/3 KSHV/HHV8(+) EBV(-)). The NHL incidence observed in this cohort study (101/1000 patient-years) is about 15-fold what is expected in the general HIV(+) population. MCD-associated KSHV/HHV8(+) NHL fell into 2 groups, suggesting different pathogenesis. The plasmablastic NHL likely represents the expansion of plasmablastic microlymphoma from the MCD lesion and progression toward aggressive NHL. In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:AgbalikaFélixF,
pubmed-author:BoshoffChrisC,
pubmed-author:BoulangerEmmanuelleE,
pubmed-author:ClauvelJean-PierreJP,
pubmed-author:DanielMarie-ThérèseMT,
pubmed-author:DissTim CTC,
pubmed-author:DuMing-QingMQ,
pubmed-author:DupinNicolasN,
pubmed-author:GalicierLionelL,
pubmed-author:HamoudiRifatR,
pubmed-author:IsaacsonPeter GPG,
pubmed-author:MeigninVéroniqueV,
pubmed-author:OksenhendlerEricE
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2331-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11895764-Antiviral Agents,
pubmed-meshheading:11895764-Cohort Studies,
pubmed-meshheading:11895764-Follow-Up Studies,
pubmed-meshheading:11895764-Gene Rearrangement,
pubmed-meshheading:11895764-Giant Lymph Node Hyperplasia,
pubmed-meshheading:11895764-HIV,
pubmed-meshheading:11895764-HIV Infections,
pubmed-meshheading:11895764-Herpesvirus 8, Human,
pubmed-meshheading:11895764-Humans,
pubmed-meshheading:11895764-Immunoglobulins,
pubmed-meshheading:11895764-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11895764-Neoplasm Staging,
pubmed-meshheading:11895764-RNA, Viral,
pubmed-meshheading:11895764-Sarcoma, Kaposi,
pubmed-meshheading:11895764-Time Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease.
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| pubmed:affiliation |
Department of Immunology and Hematology, Laboratory of Hematology, Hôpital Saint-Louis, 1 Ave Claude Vellefaux, 75010 Paris, France. eric.oksenhendler@sls.ap-hop-paris.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|