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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-3-15
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pubmed:abstractText |
This review addresses the ability of a commercially available genetic susceptibility test to determine the risk of developing severe chronic periodontitis. The test is used to detect the simultaneous occurrence of allele 2 at the IL-1A+4845 and IL-1B+3954 loci. If both of these polymorphisms are present, patients are referred to as being genotype-positive and considered predisposed to becoming afflicted with severe chronic periodontitis. A basic premise of this test is the assumption that individuals who are genotype-positive produce increased amounts of IL-beta in response to microbial lipopolysaccharides, which allegedly predisposes them to an exaggerated inflammatory response and an increased incidence of chronic periodontitis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-47
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11895290-Alleles,
pubmed-meshheading:11895290-Alveolar Bone Loss,
pubmed-meshheading:11895290-Chromosome Mapping,
pubmed-meshheading:11895290-Chronic Disease,
pubmed-meshheading:11895290-Dental Implants,
pubmed-meshheading:11895290-Forecasting,
pubmed-meshheading:11895290-Genetic Techniques,
pubmed-meshheading:11895290-Genetic Testing,
pubmed-meshheading:11895290-Genotype,
pubmed-meshheading:11895290-Gingival Hemorrhage,
pubmed-meshheading:11895290-Humans,
pubmed-meshheading:11895290-Inflammation Mediators,
pubmed-meshheading:11895290-Interleukin-1,
pubmed-meshheading:11895290-Lipopolysaccharides,
pubmed-meshheading:11895290-Periodontal Attachment Loss,
pubmed-meshheading:11895290-Periodontitis,
pubmed-meshheading:11895290-Polymorphism, Genetic,
pubmed-meshheading:11895290-Risk Assessment,
pubmed-meshheading:11895290-Tooth Loss
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pubmed:year |
2002
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pubmed:articleTitle |
A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis.
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pubmed:affiliation |
University of Medicine and Dentistry of New Jersey, Newark, USA. Hgreens123@aol.com
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pubmed:publicationType |
Journal Article,
Meta-Analysis
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