Source:http://linkedlifedata.com/resource/pubmed/id/11895146
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-3-15
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| pubmed:abstractText |
A prospective randomized study on sixty patients was conducted to investigate the effects of a fish oil containing total parenteral nutrition (TPN) regimen in the postoperative period on lymphocyte subset distribution, proliferation, cytokine production and interleukin-2 receptor (IL-2R) expression. Patients who underwent large bowel surgery were divided into three groups. Nineteen patients received TPN with fish oil (0.2 g/kg body weight per day) plus soybean oil (1.0 g/kg per day), twenty patients received soybean oil (1.2 g/kg per day), and twenty-one patients who were on a fat-free regimen served as the control group. Natural killer (NK) cells, total, B-, T-, T4-, T8-lymphocytes, proliferation of lymphocytes, in vitro production of IL-2, IFN-gamma, TNF-alpha, and IL-2R expression were measured. Fish oil administration did not affect subset distribution and proliferation of lymphocytes. Production of interleukin-2 (IL-2), interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) was augmented, and IL-2R expression less enhanced compared with the controls. It is concluded that administration of 0.2 g/kg per day fish oil after a moderate surgical stress is not immunosuppressive, but enhances the production of IFN-gamma, TNF-alpha and possibly IL-2.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Fish Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Oil
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0007-1145
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
87 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S103-10
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11895146-Aged,
pubmed-meshheading:11895146-Cytokines,
pubmed-meshheading:11895146-DNA,
pubmed-meshheading:11895146-Double-Blind Method,
pubmed-meshheading:11895146-Female,
pubmed-meshheading:11895146-Fish Oils,
pubmed-meshheading:11895146-Humans,
pubmed-meshheading:11895146-Immunity, Cellular,
pubmed-meshheading:11895146-Intestine, Large,
pubmed-meshheading:11895146-Lymphocyte Count,
pubmed-meshheading:11895146-Lymphocyte Subsets,
pubmed-meshheading:11895146-Male,
pubmed-meshheading:11895146-Middle Aged,
pubmed-meshheading:11895146-Parenteral Nutrition, Total,
pubmed-meshheading:11895146-Postoperative Care,
pubmed-meshheading:11895146-Prospective Studies,
pubmed-meshheading:11895146-Receptors, Interleukin-2,
pubmed-meshheading:11895146-Soybean Oil,
pubmed-meshheading:11895146-Stress, Physiological
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| pubmed:year |
2002
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| pubmed:articleTitle |
Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period.
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| pubmed:affiliation |
Department of Medicine, University of Göttingen, Germany. schauder@med.uni-goettingen.de
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|