Linked Life Data

11893781

Source:http://linkedlifedata.com/resource/pubmed/id/11893781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-3-14
pubmed:abstractText
Consumption of diets high in hydrogenated fat/trans fatty acids has been shown to have an adverse affect on lipoprotein profiles with respect to cardiovascular disease risk. Dietary fat and cholesterol play an important role in the regulation of immune and inflammatory responses shown to be involved in atherogenesis. We investigated the effects of diets containing hydrogenated fat on cellular immune response and production of inflammatory cytokines in human subjects with moderately elevated cholesterol levels (LDL cholesterol >130 mg/dl). In a double blind cross-over study, 19 subjects consumed three diets, 30% of calories as fat, of which two thirds were provided as soybean oil, soybean oil-based stick margarine, or butter for 32 days, each in a randomized order. Production of proinflammatory mediators, prostaglandin (PG)E(2), interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha (TNF-alpha); delayed type hypersensitivity (DTH) response, in vitro lymphocyte proliferation, and production of IL-2 were determined. Production of IL-6 and TNF-alpha was significantly higher after consumption of stick margarine diet compared with soybean oil diet. IL-1beta and TNF-alpha production correlated positively with ratios of total cholesterol to HDL cholesterol (r = 0.499, P < 0.001 and r = 0.291, P = 0.04, respectively). There was no significant difference in DTH response, lymphocyte proliferation, or levels of IL-2 and PGE(2) produced among three groups. Our results indicate that consumption of a diet high in hydrogenated fat does not adversely affect cellular immunity but increases production of inflammatory cytokines that have been associated with the pathophysiology of atherosclerosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11893781-Aged, pubmed-meshheading:11893781-Cholesterol, pubmed-meshheading:11893781-Cross-Over Studies, pubmed-meshheading:11893781-Dermatitis, Contact, pubmed-meshheading:11893781-Dietary Fats, pubmed-meshheading:11893781-Dietary Fats, Unsaturated, pubmed-meshheading:11893781-Dinoprostone, pubmed-meshheading:11893781-Double-Blind Method, pubmed-meshheading:11893781-Female, pubmed-meshheading:11893781-Humans, pubmed-meshheading:11893781-Hydrogenation, pubmed-meshheading:11893781-Hypercholesterolemia, pubmed-meshheading:11893781-Hypersensitivity, Delayed, pubmed-meshheading:11893781-Immunity, Mucosal, pubmed-meshheading:11893781-Inflammation, pubmed-meshheading:11893781-Interleukin-1, pubmed-meshheading:11893781-Interleukin-2, pubmed-meshheading:11893781-Interleukin-6, pubmed-meshheading:11893781-Leukocytes, Mononuclear, pubmed-meshheading:11893781-Lipoproteins, pubmed-meshheading:11893781-Lymphocyte Activation, pubmed-meshheading:11893781-Male, pubmed-meshheading:11893781-Middle Aged, pubmed-meshheading:11893781-Tumor Necrosis Factor-alpha
pubmed:year
2002
pubmed:articleTitle
Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia.
pubmed:affiliation
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Randomized Controlled Trial