By altering either ferric chloride concentration in 10% citric acid (1% ferric chloride = 10-1; 5% ferric chloride = 10-5; 10% ferric chloride = 10-10) or conditioning periods with an aqueous mixture of 1% citric acid and 1% ferric chloride (1-1), the influence of dentin substrate on bond strength and hybridized dentin in wet bonding of 4-META/MMA-TBB resin was examined.