|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2002-3-14
|
|
pubmed:abstractText |
Variants that no longer express an entire H-2 haplotype were readily isolated, by immunoselection with antisera directed against the haplotype, from an H-2b/H-2d heterozygous Friend leukemia cell line carrying a Robertsonian translocation of the chromosomes bearing the H-2 genetic region. These variants can be denoted as being of the phenotype H-2b- H-2d+ or H-2b+ H-2d-. Some of the H-2b- H-2d+ variants: (1) lack the restriction enzyme fragments characteristic of the missing H-2b haplotype, as assessed by Southern blot analysis; (2) express more cell surface H-2d antigens than wild-type cells, as assessed by flow microfluorimetry; and (3) appear to have become homozygous for the more active H-2d-linked allele at the Glyoxalase I locus. These variants thus seem to have lost genetic material corresponding to the H-2b haplotype and may have gained genetic material corresponding to the H-2d haplotype. These results are consistent with the possibility that these variants were generated by mitotic recombination.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-1138914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6276757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6283386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6786753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6788845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6952248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-6961455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-7063041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-744475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11892808-910130
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0261-4189
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1537-42
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11892808-Animals,
pubmed-meshheading:11892808-Blotting, Southern,
pubmed-meshheading:11892808-Gene Expression,
pubmed-meshheading:11892808-Genetic Variation,
pubmed-meshheading:11892808-H-2 Antigens,
pubmed-meshheading:11892808-Haplotypes,
pubmed-meshheading:11892808-Heterozygote,
pubmed-meshheading:11892808-Lactoylglutathione Lyase,
pubmed-meshheading:11892808-Mice,
pubmed-meshheading:11892808-Mitosis,
pubmed-meshheading:11892808-Models, Genetic,
pubmed-meshheading:11892808-Mutation,
pubmed-meshheading:11892808-Recombination, Genetic,
pubmed-meshheading:11892808-Translocation, Genetic,
pubmed-meshheading:11892808-Tumor Cells, Cultured
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
H-2 hemizygous mutants from a heterozygous cell line: role of mitotic recombination.
|
|
pubmed:affiliation |
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
