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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-3-13
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pubmed:abstractText |
delta-Catenin associates with adhesive junctions and facilitates cellular morphogenesis (Lu et al., 1999). Here we show that delta-catenin colocalizes with actin filaments and Abl tyrosine kinase in the growth cones of cultured hippocampal neurons. PC12 cells induced to express delta-catenin show accelerated neurite extension upon nerve growth factor (NGF) stimulation. STI571, an Abl family kinase inhibitor, further accentuates these stimulatory effects. delta-Catenin is a potent substrate for Abl in vitro using an immunocomplex assay and most of the Abl-induced tyrosine phosphorylation within cells is present in the N-terminus of delta-catenin. When delta-catenin-expressing epithelial cells are induced to scatter in response to hepatocyte growth factor (HGF), STI571 leads to the rapid redistribution of delta-catenin and changes in cellular morphology. We suggest that delta-catenin is a possible Abl substrate and acts downstream of Abl to orchestrate actin-based cellular morphogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0360-4012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
618-24
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11891774-Actin Cytoskeleton,
pubmed-meshheading:11891774-Animals,
pubmed-meshheading:11891774-Armadillo Domain Proteins,
pubmed-meshheading:11891774-Brain,
pubmed-meshheading:11891774-Catenins,
pubmed-meshheading:11891774-Cell Adhesion Molecules,
pubmed-meshheading:11891774-Cell Differentiation,
pubmed-meshheading:11891774-Cytoskeletal Proteins,
pubmed-meshheading:11891774-Enzyme Inhibitors,
pubmed-meshheading:11891774-Fetus,
pubmed-meshheading:11891774-Growth Cones,
pubmed-meshheading:11891774-Growth Substances,
pubmed-meshheading:11891774-Immunohistochemistry,
pubmed-meshheading:11891774-Mice,
pubmed-meshheading:11891774-Nucleic Acid Synthesis Inhibitors,
pubmed-meshheading:11891774-PC12 Cells,
pubmed-meshheading:11891774-Phosphoproteins,
pubmed-meshheading:11891774-Phosphorylation,
pubmed-meshheading:11891774-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:11891774-Rats
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pubmed:year |
2002
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pubmed:articleTitle |
Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors.
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pubmed:affiliation |
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA. luq@mail.ecu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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