| pubmed-article:11891526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C1879526 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C1882628 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C0487602 | lld:lifeskim |
| pubmed-article:11891526 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:11891526 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11891526 | pubmed:dateCreated | 2002-3-13 | lld:pubmed |
| pubmed-article:11891526 | pubmed:abstractText | We previously showed that colitis enhanced the development of cancer and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in Fischer 344 rats. In this study, we examined the effect of two different anti-inflammatory drugs [non-steroidal anti-inflammatory drugs (NSAIDs: Fenbufen) and a platelet activating factor-receptor antagonist (PAF-RA)] on the inflammation-induced rat colon carcinogenesis. Furthermore, we examined the expression and the localization of beta-catenin protein, and the proliferating cell nuclear antigen (PCNA)-labeling index (LI) in ACF and cancer. PAF-RA significantly decreased the incidence of ACF in the rats (p<0.05), but Fenbufen did not affect the incidence of ACF and cancer. In most of the ACF (91%), beta-catenin was localized at the cell membrane like in normal colon epithelium. In about 9% of the ACF, beta-catenin was overexpressed not only on the cell membrane but also in the cytoplasm. In all of the cancer cells, beta-catenin was overexpressed in the nucleus. When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF. These findings suggest that immunohistochemical staining of ACF for beta-catenin can evaluate the malignant potential of ACF, and that PAF-RA can be used for preventing the development of ACF in inflammation-induced carcinogenesis. | lld:pubmed |
| pubmed-article:11891526 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11891526 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11891526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11891526 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11891526 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:11891526 | pubmed:author | pubmed-author:KubotaKeiichi... | lld:pubmed |
| pubmed-article:11891526 | pubmed:author | pubmed-author:KawamataHitos... | lld:pubmed |
| pubmed-article:11891526 | pubmed:author | pubmed-author:FujimoriTakah... | lld:pubmed |
| pubmed-article:11891526 | pubmed:author | pubmed-author:FurihataTadas... | lld:pubmed |
| pubmed-article:11891526 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11891526 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11891526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11891526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11891526 | pubmed:pagination | 353-8 | lld:pubmed |
| pubmed-article:11891526 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11891526 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11891526 | pubmed:articleTitle | Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for beta-catenin in inflammation-induced rat colon carcinogenesis. | lld:pubmed |
| pubmed-article:11891526 | pubmed:affiliation | Department of Gastroenterological Surgery, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. | lld:pubmed |
| pubmed-article:11891526 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11891526 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11891526 | lld:pubmed |
