Source:http://linkedlifedata.com/resource/pubmed/id/11891526
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2002-3-13
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| pubmed:abstractText |
We previously showed that colitis enhanced the development of cancer and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in Fischer 344 rats. In this study, we examined the effect of two different anti-inflammatory drugs [non-steroidal anti-inflammatory drugs (NSAIDs: Fenbufen) and a platelet activating factor-receptor antagonist (PAF-RA)] on the inflammation-induced rat colon carcinogenesis. Furthermore, we examined the expression and the localization of beta-catenin protein, and the proliferating cell nuclear antigen (PCNA)-labeling index (LI) in ACF and cancer. PAF-RA significantly decreased the incidence of ACF in the rats (p<0.05), but Fenbufen did not affect the incidence of ACF and cancer. In most of the ACF (91%), beta-catenin was localized at the cell membrane like in normal colon epithelium. In about 9% of the ACF, beta-catenin was overexpressed not only on the cell membrane but also in the cytoplasm. In all of the cancer cells, beta-catenin was overexpressed in the nucleus. When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF. These findings suggest that immunohistochemical staining of ACF for beta-catenin can evaluate the malignant potential of ACF, and that PAF-RA can be used for preventing the development of ACF in inflammation-induced carcinogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylbutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/fenbufen,
http://linkedlifedata.com/resource/pubmed/chemical/platelet activating factor receptor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1107-3756
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
9
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
353-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11891526-Animals,
pubmed-meshheading:11891526-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11891526-Cell Division,
pubmed-meshheading:11891526-Colitis, Ulcerative,
pubmed-meshheading:11891526-Colonic Neoplasms,
pubmed-meshheading:11891526-Cytoskeletal Proteins,
pubmed-meshheading:11891526-Intestinal Mucosa,
pubmed-meshheading:11891526-Male,
pubmed-meshheading:11891526-Phenylbutyrates,
pubmed-meshheading:11891526-Platelet Membrane Glycoproteins,
pubmed-meshheading:11891526-Rats,
pubmed-meshheading:11891526-Rats, Inbred F344,
pubmed-meshheading:11891526-Receptors, Cell Surface,
pubmed-meshheading:11891526-Receptors, G-Protein-Coupled,
pubmed-meshheading:11891526-Trans-Activators,
pubmed-meshheading:11891526-Tumor Markers, Biological,
pubmed-meshheading:11891526-beta Catenin
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| pubmed:year |
2002
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| pubmed:articleTitle |
Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for beta-catenin in inflammation-induced rat colon carcinogenesis.
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| pubmed:affiliation |
Department of Gastroenterological Surgery, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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