Source:http://linkedlifedata.com/resource/pubmed/id/11891147
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-3-13
|
| pubmed:abstractText |
The objective of this preliminary uncontrolled study was twofold: First, to assess the feasibility of retinyl palmitate inhalation and second, to analyze the changes of metaplastic lesions of the respiratory epithelium (metaplasia or dysplasia) following retinyl palmitate inhalation. The response to a daily dose of 18.000 I.U. retinyl palmitate by inhalation over a period of 3 month was assessed in 11 subjects (9 smokers, 2 ex-smokers). Using white-light bronchoscopy combined with autofluorescence bronchoscopy, bronchial biopsies were taken before and after a 3 month-period. The biopsy samples were evaluated blind by a referee lung pathologist. The overall response rate (remission or partial remission) was 56% (95% CI 0.30 0.79; p<0.05). These data suggest that inhalation of retinyl esters could be a promising therapeutical approach for chemoprevention of lung cancer. Vitamin A; chemoprevention; lung cancer; squamous metaplasia; dysplasia; retinoids
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0949-2321
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
72-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11891147-Administration, Inhalation,
pubmed-meshheading:11891147-Aerosols,
pubmed-meshheading:11891147-Biopsy,
pubmed-meshheading:11891147-Bronchi,
pubmed-meshheading:11891147-Bronchoscopy,
pubmed-meshheading:11891147-Female,
pubmed-meshheading:11891147-Fluorescence,
pubmed-meshheading:11891147-Hoarseness,
pubmed-meshheading:11891147-Humans,
pubmed-meshheading:11891147-Male,
pubmed-meshheading:11891147-Metaplasia,
pubmed-meshheading:11891147-Middle Aged,
pubmed-meshheading:11891147-Pilot Projects,
pubmed-meshheading:11891147-Precancerous Conditions,
pubmed-meshheading:11891147-Prospective Studies,
pubmed-meshheading:11891147-Remission Induction,
pubmed-meshheading:11891147-Respiratory Mucosa,
pubmed-meshheading:11891147-Smoking,
pubmed-meshheading:11891147-Treatment Outcome,
pubmed-meshheading:11891147-Vitamin A
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Inhalation of aerosolized vitamin a: reversibility of metaplasia and dysplasia of human respiratory epithelia -- a prospective pilot study.
|
| pubmed:affiliation |
Asklepios Center for Respiratory Medicine and Thoracic Surgery, Munich-Gauting, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|