Linked Life Data

11890748

Source:http://linkedlifedata.com/resource/pubmed/id/11890748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-3-13
pubmed:abstractText
The reaction of the S-nitrosothiol compound N-acetyl-1-amino-2-methylpropyl-2-thionitrite (RSNO) with the model metalloporphyrin complex Ru(II)(OEP)(CO) (OEP = octaethylporphyrinato dianion) gives the addition product trans-Ru(II)(OEP)(NO)(SR). Here we report the details of a stopped flow kinetics investigation which demonstrates the rapid equilibrium formation of an intermediate concluded to be S-bound RSNO complex Ru(II)(OEP)(RSNO)(CO), which undergoes a rate-limiting step, presumably S-NO bond cleavage to give a second intermediate Ru(III)(OEP)(SR)(CO) too short lived for direct observation. Notably, this is different from the nitrogen coordination pathway often proposed and represents an alternative mechanism by which S-nitrosothiols may be formed or decomposed in the presence of redox active metal centers. Also reported is a brief study of the quantitative photochemistry of RSNO, the photodecomposition of which complicates the kinetics studies by spectroscopic techniques.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1089-8603
pubmed:author
pubmed:copyrightInfo
(C)2001 Elsevier Science (USA).
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-35
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Kinetics studies of the reaction of the ruthenium porphyrin Ru(OEP)(CO) with the S-nitrosothiol N-acetyl-1-amino-2-methylpropyl-2-thionitrite.
pubmed:affiliation
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't