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pubmed-article:11888582pubmed:abstractTextThe use of abacavir--a potent HIV-1 nucleoside-analogue reverse-transcriptase inhibitor--is complicated by a potentially life-threatening hypersensitivity syndrome in about 5% of cases. Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir.lld:pubmed
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pubmed-article:11888582pubmed:articleTitleAssociation between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.lld:pubmed
pubmed-article:11888582pubmed:affiliationCentre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia. mallal@prodigal.murdoch.edu.aulld:pubmed
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