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pubmed-article:11886574pubmed:abstractTextNeonatal alloimmune thrombocytopenia (NAIT) can occur when a mother is immunized against fetal platelet antigens inherited from the father. Early diagnosis and appropriate platelet transfusion therapy are essential to prevent life-threatening intracranial hemorrhage in the thrombocytopenic fetus or neonate. Five major human platelet antigen (HPA) systems are capable of causing this disorder with HPA-1a indicated most frequently. This article reviews the pathophysiology, clinical aspects, and management of NAIT. We also present our experience with treatment of neonates affected with this disorder.lld:pubmed
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pubmed-article:11886574pubmed:dateRevised2006-8-26lld:pubmed
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pubmed-article:11886574pubmed:articleTitleNeonatal alloimmune thrombocytopenia.lld:pubmed
pubmed-article:11886574pubmed:affiliationDepartment of Pathology, Indiana University Hospital, Indianapolis, Indiana 46202, USA.lld:pubmed
pubmed-article:11886574pubmed:publicationTypeJournal Articlelld:pubmed
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