Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-3-11
pubmed:abstractText
Intradermal injection of substance P elicits an itch sensation in human subjects and an itch-associated response in mice. The substance P-induced itch-associated response in mice is not inhibited by antihistamine. Therefore, the mechanisms of substance P-induced itch-associated response are unclear. In this study, we demonstrated one of the mechanisms. Substance P induces an arachidonate cascade to produce prostaglandins and leukotriene. In this study we considered whether arachidonate metabolites are involved in the substance P-induced itch-associated response. A phospholipase A(2) inhibitor arachidoryltrifluoromethyl ketone inhibited the substance P-induced itch-associated response in mice. Pre treatment with the glucocorticoids betamethasone and dexamethasone also produced inhibition of the substance P-induced itch-associated response in mice as well as humans. The 5-lipoxygenase inhibitor zileuton, but not the cyclooxygenase inhibitors indomethacin and diclofenac, suppressed substance P-induced itch-associated response. The leukotriene B(4) receptor antagonist 5-[2-(2-carboxyethyl)-3-[6-(4-methoxyphenyl)-5E-hexenyl]oxyphenoxy]valeric acid produced inhibition, whereas pranlukast (leukotriene C(4)/D(4)/E(4) receptor antagonist) and 5(Z)-7-[1S,2S, 3S,5R-3-(trans-b-styren)sulfonamido-6,6-dimethylbi cyclo(3,1,1)hept-2-yl]-5-heptenoic acid (EP(1) receptor antagonist) were without effect. Furthermore, when the production of leukotriene B(4) and prostaglandin E(2) was measured in skin injected with substance P and in mouse keratinocytes applied with substance P, the level of both products increased. As leukotriene B(4), but not prostaglandin E(2), also induces the itch-associated response in mice, these results suggest that leukotriene B(4) and keratinocytes, cutaneous cells which produced leukotriene B(4), play an important role in substance P-induced itch-scratch response in mice. Leukotriene B(4) receptor antagonist and 5-lipoxygenase inhibitor may be novel antipruritic drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 5-Lipoxygenase, http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin, http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4, http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/ONO-LB 457, http://linkedlifedata.com/resource/pubmed/chemical/Phenylpropionates, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene B4, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1, http://linkedlifedata.com/resource/pubmed/chemical/Substance P, http://linkedlifedata.com/resource/pubmed/chemical/arachidonyltrifluoromethane
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1621-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11886531-Animals, pubmed-meshheading:11886531-Arachidonate 5-Lipoxygenase, pubmed-meshheading:11886531-Arachidonic Acid, pubmed-meshheading:11886531-Arachidonic Acids, pubmed-meshheading:11886531-Cyclooxygenase Inhibitors, pubmed-meshheading:11886531-Dexamethasone, pubmed-meshheading:11886531-Dinoprostone, pubmed-meshheading:11886531-Enzyme Inhibitors, pubmed-meshheading:11886531-Glucocorticoids, pubmed-meshheading:11886531-Immunosuppressive Agents, pubmed-meshheading:11886531-Indomethacin, pubmed-meshheading:11886531-Keratinocytes, pubmed-meshheading:11886531-Leukotriene B4, pubmed-meshheading:11886531-Lipoxygenase Inhibitors, pubmed-meshheading:11886531-Male, pubmed-meshheading:11886531-Mast Cells, pubmed-meshheading:11886531-Mice, pubmed-meshheading:11886531-Mice, Inbred ICR, pubmed-meshheading:11886531-Mice, Mutant Strains, pubmed-meshheading:11886531-Phenylpropionates, pubmed-meshheading:11886531-Phospholipases A, pubmed-meshheading:11886531-Pruritus, pubmed-meshheading:11886531-Receptors, Leukotriene B4, pubmed-meshheading:11886531-Receptors, Neurokinin-1, pubmed-meshheading:11886531-Substance P
pubmed:year
2001
pubmed:articleTitle
Involvement of leukotriene B(4) in substance P-induced itch-associated response in mice.
pubmed:affiliation
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't