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rdf:type |
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lifeskim:mentions |
umls-concept:C0003209,
umls-concept:C0017262,
umls-concept:C0021747,
umls-concept:C0021758,
umls-concept:C0040690,
umls-concept:C0185117,
umls-concept:C0851285,
umls-concept:C0851827,
umls-concept:C0913092,
umls-concept:C1332707,
umls-concept:C1415900,
umls-concept:C1701901,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2002-3-8
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pubmed:abstractText |
Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) is a monocyte-derived dendritic cell (MDDC)-specific lectin which participates in dendritic cell (DC) migration and DC-T lymphocyte interactions at the initiation of immune responses and enhances trans-infection of T cells through its HIV gp120-binding ability. The generation of a DC-SIGN-specific mAb has allowed us to determine that the acquisition of DC-SIGN expression during the monocyte-DC differentiation pathway is primarily induced by IL-4, and that GM-CSF cooperates with IL-4 to generate a high level of DC-SIGN mRNA and cell surface expression on immature MDDC. IL-4 was capable of inducing DC-SIGN expression on monocytes without affecting the expression of other MDDC differentiation markers. By contrast, IFN-alpha, IFN-gamma, and TGF-beta were identified as negative regulators of DC-SIGN expression, as they prevented the IL-4-dependent induction of DC-SIGN mRNA on monocytes, and a similar inhibitory effect was exerted by dexamethasone, an inhibitor of the monocyte-MDDC differentiation pathway. The relevance of the inhibitory action of dexamethasone, IFN, and TGF-beta on DC-SIGN expression was emphasized by their ability to inhibit the DC-SIGN-dependent HIV-1 binding to differentiating MDDC. These results demonstrate that DC-SIGN, considered as a MDDC differentiation marker, is a molecule specifically expressed on IL-4-treated monocytes, and whose expression is subjected to a tight regulation by numerous cytokines and growth factors. This feature might help in the development of strategies to modulate the DC-SIGN-dependent cell surface attachment of HIV for therapeutic purposes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferons,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2634-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11884427-Animals,
pubmed-meshheading:11884427-Anti-Inflammatory Agents,
pubmed-meshheading:11884427-Antibodies, Monoclonal,
pubmed-meshheading:11884427-Cell Adhesion Molecules,
pubmed-meshheading:11884427-Cell Differentiation,
pubmed-meshheading:11884427-Dendritic Cells,
pubmed-meshheading:11884427-Dexamethasone,
pubmed-meshheading:11884427-Down-Regulation,
pubmed-meshheading:11884427-Humans,
pubmed-meshheading:11884427-Immunosuppressive Agents,
pubmed-meshheading:11884427-Interferons,
pubmed-meshheading:11884427-Interleukin-4,
pubmed-meshheading:11884427-K562 Cells,
pubmed-meshheading:11884427-Lectins,
pubmed-meshheading:11884427-Lectins, C-Type,
pubmed-meshheading:11884427-Mice,
pubmed-meshheading:11884427-Mice, Inbred BALB C,
pubmed-meshheading:11884427-Monocytes,
pubmed-meshheading:11884427-RNA, Messenger,
pubmed-meshheading:11884427-Receptors, Cell Surface,
pubmed-meshheading:11884427-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents.
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pubmed:affiliation |
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, and Servicio de Inmuno-oncología and Servicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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