Linked Life Data

11884032

Source:http://linkedlifedata.com/resource/pubmed/id/11884032

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pubmed-article:11884032pubmed:abstractTextThe heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative timing of diverse developmental events during the animal's larval stages. lin-28 is stage-specifically regulated by two genetic circuits: negatively by the 22-nt RNA lin-4 and positively by the heterochronic gene lin-14. Here, we show that lin-28 is repressed during normal development by a mechanism that acts on its mRNA after translation initiation. We provide evidence that lin-14 inhibits a negative regulation that is independent of the lin-4 RNA and involves the gene daf-12, which encodes a nuclear hormone receptor. The lin-4-independent repression does not affect the initiation of translation on the lin-28 mRNA, and like the lin-4-mediated repression, acts through the gene's 3'-untranslated region. In addition, we find that lin-4 is not sufficient to cause repression of lin-28 if the lin-4-independent circuit is inhibited. Therefore, the lin-4-independent circuit likely contributes substantially to the down-regulation of lin-28 that occurs during normal development. The role of lin-4 may be to initiate or potentiate the lin-4-independent circuit. We speculate that a parallel lin-4-independent regulatory mechanism regulates the expression of lin-14.lld:pubmed
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pubmed-article:11884032pubmed:authorpubmed-author:MossEric GEGlld:pubmed
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pubmed-article:11884032pubmed:copyrightInfo(C)2002 Elsevier Science (USA).lld:pubmed
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pubmed-article:11884032pubmed:articleTitleTwo genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation.lld:pubmed
pubmed-article:11884032pubmed:affiliationFox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.lld:pubmed
pubmed-article:11884032pubmed:publicationTypeJournal Articlelld:pubmed
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