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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-3-8
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pubmed:abstractText |
Increasing evidence points to a close relationship between the autonomic nervous system and the immune system. To further investigate mechanisms regulating beta2-adrenergic receptor (beta2R) expression in lymphocytes, the influence of cytokines on the density of beta2R on purified CD4+ and CD8+ lymphocytes was determined in vitro. beta2R were determined by means of a radioligand binding assay with (125I)iodocyanopindolol. CD4+ and CD8+ lymphocytes were incubated with catecholamines, interleukin 1beta (IL-1beta) and interleukin 2 (IL-2) for 6-72 h. The results demonstrate declining beta2R numbers on CD4+ and CD8+ lymphocytes in vitro augmented by epinephrine. IL-1beta has no effect on beta2R expression compared to medium. However, incubation with IL-2 resulted in an up-regulation of beta2R on CD8+ lymphocytes. Thus, the study demonstrates a differential regulation of beta2R on T-lymphocyte subpopulations with CD8+ lymphocytes being more susceptible to mechanisms of beta2R modulation than CD4+ lymphocytes. The findings further strengthen the concept of a close interplay between the autonomic nervous system and the immune system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1043-4666
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11884023-Adrenergic alpha-Agonists,
pubmed-meshheading:11884023-Adrenergic beta-Agonists,
pubmed-meshheading:11884023-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11884023-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11884023-Cells, Cultured,
pubmed-meshheading:11884023-Cytokines,
pubmed-meshheading:11884023-Epinephrine,
pubmed-meshheading:11884023-Humans,
pubmed-meshheading:11884023-Interleukin-1,
pubmed-meshheading:11884023-Interleukin-2,
pubmed-meshheading:11884023-Kinetics,
pubmed-meshheading:11884023-Nervous System,
pubmed-meshheading:11884023-Norepinephrine,
pubmed-meshheading:11884023-Protein Binding,
pubmed-meshheading:11884023-Radioligand Assay,
pubmed-meshheading:11884023-Receptors, Adrenergic, beta-2,
pubmed-meshheading:11884023-Time Factors,
pubmed-meshheading:11884023-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Regulation of beta2-adrenergic receptors on CD4 and CD8 positive lymphocytes by cytokines in vitro.
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pubmed:affiliation |
Department of Medicine IV, University Hospital Leipzig, Leipzig, Germany. wahm@medizin.uni-leipzig.de
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pubmed:publicationType |
Journal Article,
In Vitro
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