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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-7
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pubmed:abstractText |
Since the central hallmarks of human multiple myeloma (MM) are abnormalities in immunoglobulin (Ig) gene rearrangement, IgH class switching, and DNA damage repair, and since Ku86 and Ku70 proteins are central to these processes, aberrant Ku function may play a role in MM pathogenesis. Our prior studies demonstrated a 69-kDa Ku86 variant in freshly isolated patient MM cells that confers sensitivity to DNA damage. We also showed that Ku86 on the cell surface of CD40-activated MM cells mediates homotypic tumor cell adhesion, as well as heterotypic adhesion to bone marrow stromal cells. We here define the mechanism and functional significance of CD40-induced Ku translocation from the cytoplasm to the cell membrane in MM cells vs normal B cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Ku autoantigen,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/XRCC5 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11882358-Antigens, CD40,
pubmed-meshheading:11882358-Antigens, Nuclear,
pubmed-meshheading:11882358-Apoptosis,
pubmed-meshheading:11882358-B-Lymphocytes,
pubmed-meshheading:11882358-Biological Transport,
pubmed-meshheading:11882358-Cell Adhesion,
pubmed-meshheading:11882358-Cell Fractionation,
pubmed-meshheading:11882358-Cell Membrane,
pubmed-meshheading:11882358-Cytoplasm,
pubmed-meshheading:11882358-DNA Helicases,
pubmed-meshheading:11882358-DNA-Binding Proteins,
pubmed-meshheading:11882358-Doxorubicin,
pubmed-meshheading:11882358-Fibronectins,
pubmed-meshheading:11882358-Flow Cytometry,
pubmed-meshheading:11882358-Fluorescent Antibody Technique,
pubmed-meshheading:11882358-Humans,
pubmed-meshheading:11882358-Multiple Myeloma,
pubmed-meshheading:11882358-Nuclear Proteins,
pubmed-meshheading:11882358-Palatine Tonsil
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pubmed:year |
2002
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pubmed:articleTitle |
Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications.
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pubmed:affiliation |
The Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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