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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-3-6
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pubmed:abstractText |
3-Nitrotyrosine (3-NT), a product of peroxynitrite reaction, is abundantly observed in hepatocytes adjacent to human metastatic colorectal carcinoma. To elucidate its biological significance, we undertook to identify nitric oxide (NO)-producing cells and apoptosis under oxidative stress. We observed strong inducible NO-synthase (iNOS) immunoreactivity in the hepatocytes adjacent to metastatic tumor, revealing an identical pattern to 3-NT immunostaining. Furthermore, intense 3-NT immunostaining of hepatocytes was associated with apoptosis whereas carcinoma cells near those hepatocytes presented high proliferating-cell nuclear antigen. Our results suggest that contact of metastatic tumor induces apoptosis in adjacent hepatocytes through peroxynitrite, thus permitting the proliferation of cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/peroxynitric acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-93
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:11880186-Adenocarcinoma,
pubmed-meshheading:11880186-Aged,
pubmed-meshheading:11880186-Apoptosis,
pubmed-meshheading:11880186-Cell Division,
pubmed-meshheading:11880186-Colorectal Neoplasms,
pubmed-meshheading:11880186-Female,
pubmed-meshheading:11880186-Humans,
pubmed-meshheading:11880186-Immunoenzyme Techniques,
pubmed-meshheading:11880186-Liver Neoplasms,
pubmed-meshheading:11880186-Male,
pubmed-meshheading:11880186-Middle Aged,
pubmed-meshheading:11880186-Nitrates,
pubmed-meshheading:11880186-Nitric Oxide,
pubmed-meshheading:11880186-Nitric Oxide Synthase,
pubmed-meshheading:11880186-Nitric Oxide Synthase Type II,
pubmed-meshheading:11880186-Oxidants,
pubmed-meshheading:11880186-Oxidative Stress,
pubmed-meshheading:11880186-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11880186-Reactive Oxygen Species,
pubmed-meshheading:11880186-Tyrosine
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pubmed:year |
2002
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pubmed:articleTitle |
Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.
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pubmed:affiliation |
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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