Linked Life Data

1187955

Source:http://linkedlifedata.com/resource/pubmed/id/1187955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-1-23
pubmed:abstractText
Rats were initially trained to discriminate LSD from saline in two-lever operant chambers by reinforcing responses only on one lever following intraperitoneal injections of 80 mug/kg of LSD and only on the other lever following saline injections. Choice responding during extinction periods (no water reinforcement for either response) indicated a high level of discriminability (95% correct) following either LSD or saline. A dose-response curve for LSD, obtained by tests for lever choice after injections of 10, 20, 30, 40, 50, and 60 mug/kg, indicated that 10 mug/kg produced only 30% responding on the LSD lever. This percentage was increased (to 83%) by reinforcing responding on the LSD lever following injections of 10 mug/kg. Subsequent tests indicated that doses of 5.0 and 2.5 mug/kg produced a majority of responses on the LSD lever. Since at these low doses LSD has few measurable biochemical or behavioral effects, we hypothesized that the discriminable cue of LSD is related to direct stimulation of central serotonergic receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Behaviorally induced sensitivity to the discriminable properties of LSD.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.